ArchiveJuly 2016

Game over the ref has stopped the transfer market

The Research Excellence Framework (REF) is a method of how the UK Government assesses Reserach Excellence and this dictates how it gives £2 billion a year to Higher Education Centres. This occurs every 5-6 years and the next one in in 2020/2021. In the past the Universities have selected who they return (you only get paid for those you submit), based on their performance which influences their...

Benign MS

Zivadinov R, Cookfair DL, Krupp L, Miller AE, Lava N, Coyle PK, Goodman AD, Jubelt B, Lenihan M, Herbert J, Gottesman M, Snyder DH, Apatoff BR, Teter BE, Perel AB, Munschauer F, Weinstock-Guttman B. Factors associated with benign multiple sclerosis in the New York State MS Consortium (NYSMSC).BMC Neurol. 2016 Jul 15;16(1):102. doi: 10.1186/s12883-016-0623-2. BACKGROUND:This retrospective...

Need for Spasticity Agents

Rønning OM, Tornes KD.Need for symptomatic management in advanced multiple sclerosis. Acta Neurol Scand. 2016. doi: 10.1111/ane.12631. [Epub ahead of print] OBJECTIVE:A majority of patients with advanced multiple sclerosis (MS) need symptomatic treatment. Many MS-related symptoms may not be recognized and thus are not treated. We conducted a study to estimate the prevalence of inadequate...

The Sixth Amendment-Spasticity trial

The Sixth Amendment of the US constitution guarantees the right to a Speedy Trial and Impartial panel of Assessors (Jury).We want to do the same.  Double blind trials have a impartial set of assessors who are there to monitor the good and bad effects of any test drug but how do we make it more speedy…..simple its the Sixth Amendment.  Every time you want to change anything in the...

Learning from other conditions may teach us something-Obrigado

Meyer S, Woodward M, Hertel C, Vlaicu P, Haque Y, Kärner J, Macagno A, Onuoha SC, Fishman D, Peterson H, Metsküla K, Uibo R, Jäntti K, Hokynar K, Wolff AS; APECED patient collaborative, Krohn K, Ranki A, Peterson P, Kisand K, Hayday A.AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell. 2016 Jul 14. pii: S0092-8674(16)30792-9. APS1/APECED patients...

MS a B cell disease…..Wait a minute on not quite yet, T cells are hanging on

Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M. Features of Human CD3+CD20+ T Cells. J Immunol. 2016 Jul 13. pii: 1600089. [Epub ahead of print] Monoclonal Abs against CD20 reduce the number of relapses in multiple sclerosis (MS); commonly this effect is solely attributed to...

B Regulatory Cells

Piancone F, Saresella M, Marventano I, La Rosa F, Zoppis M, Agostini S, Longhi R, Caputo D, Mendozzi L, Rovaris M, Clerici M.B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity. Sci Rep. 2016 Jul 14;6:29699. doi: 10.1038/srep29699. B lymphocytes contribute to the pathogenesis of Multiple Sclerosis (MS) by secreting antibodies and...

Progressive dwindling

PLoS One. 2016 Jul 21;11(7):e0159210. doi: 10.1371/journal.pone.0159210. Progressive Dwindling in Multiple Sclerosis: An Opportunity to Improve Care. Martin JE, Raffel J, Nicholas R. Abstract INTRODUCTION: In the general ageing population, 40% of deaths occur following a prolonged trajectory of “progressive dwindling,” characterised by chronic accumulation of disability and frailty...

Th17 important in MS

Bühler U, Fleischer V, Luessi F, Rezk A, Belikan P, Graetz C, Gollan R, Wolf C, Lutz J, Bar-Or A, Siffrin V, Zipp F. Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment. Mult Scler. 2016 . pii: 1352458516658559. [Epub ahead of print] OBJECTIVE: Natalizumab is known to prevent T-helper cells entering the central nervous system (CNS). We hypothesize...

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