I am sick and tired of my current DMT; it seems to be affecting wound healing. What about you? #SurveySpeak #MSBlog
“Prof B (aka the MouseDoctor) was speaking to a person with MS who mentioned to him that since starting drug X they had noticed that minor cuts and abrasions were taking much longer to heal. The process of wound healing is complex and uses many of the same biological processes that the immune system uses to function. Therefore it is quite possible that some DMTs that are used in MS may impact on wound healing. To assess whether or not this is an anecdote, or a real phenomenon, ProfB has asked me to do a quick poll. We would therefore appreciate it if you could complete the following survey. Thank you.”
Eming et al. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014 Dec 3;6(265):265sr6.
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body’s natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.