ArchiveSeptember 2016

Location, location, location: MS pathology preferentially affects the edges of the brain

The Paper Objective To assess the association between proximity to the inner (ventricular and aqueductal) and outer (pial) surfaces of the brain and the distribution of normal appearing white matter (NAWM) and grey matter (GM) abnormalities, and white matter (WM) lesions, in multiple sclerosis (MS). Methods 67 people with relapse-onset MS and 30 healthy controls were included in the...

How does laquinimod block attacks

Kaye J, Piryatinsky V, Birnberg T, Hingaly T, Raymond E, Kashi R, Amit-Romach E, Caballero IS, Towfic F, Ator MA, Rubinstein E, Laifenfeld D, Orbach A, Shinar D, Marantz Y, Grossman I, Knappertz V, Hayden MR, Laufer R. Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2016. pii: 201607843. [Epub ahead of print]...

#GuestPost #ThinkHand, #ECTRIMS2016: Professor Coyle’s motion at the “Burning Debate”

Last week I posted my slides in favour of the motion that pwMS in wheelchairs should be included in DMT trials. You were asking to learn more about the motion against, and my opponent during the ‘burning debate’ at ECTRIMS 2016, Patricia Coyle, kindly agreed to share her slides and some key points of her argument for this Guestpost. Patricia K. Coyle, MD, FAAN, FANA, is...

Making Microglia

Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R. Efficient derivation of microglia-like cells from human pluripotent stem cells. Nat Med. 2016. doi: 10.1038/nm.4189. [Epub ahead of print] Microglia, the only lifelong resident immune cells of the central nervous system (CNS), are highly specialized macrophages that have been...

EBV and smoking in MS: Two peas in a pod?

Negative interaction between smoking and EBV in the risk of multiple sclerosis: The EnvIMS study Published online before print September 23, 2016, doi: 10.1177/1352458516671028 Kjetil Bjørnevik, Trond Riise,Inger Bostrom, llaria Casetta,Marianna Cortese,Enrico Granieri,Trygve Holmøy,Margitta T Kampman,Anne-Marie Landtblom,Sandra Magalhaes,Maura Pugliatti,Christina Wolfson,Kjell-Morten Myhr...

Comparing DMT

Comparative efficacy of disease-modifying therapies for patients with relapsing remitting multiple sclerosis: Systematic review and network meta-analysis. Fogarty E, Schmitz S, Tubridy N, Walsh C, Barry M.Mult Scler Relat Disord. 2016 Sep;9:23-30. doi: 10.1016/j.msard.2016.06.001. Epub 2016 Jun 8. PMID: INTRODUCTION:Randomised studies have demonstrated efficacy of disease-modifying therapies in...

Demystifying vitamin D: new study links variants in vitamin D genes to risk of MS

Abstract Objective: We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality. Methods: We conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D...

#ResearchSpeak, #ThinkHand, #ECTRIMS2016: My motion at the “Burning Debate”

At last week’s ECTRIMS we took a variety of approaches to highlight upper limb function and the fact that pwMS who have limited, or no, lower limb function are hardly ever considered for DMT trials.  You’ve read about our cardboard 9-hole-peg-test, the hand made poster I presented in the far corner of the poster hall (nevertheless visible due to helium baloons reporting the key...

HSCT a Hot Topic

ECTRIMS had a hot topic debate Bone marrow transplantation is a justifiable treatment for active relapsing multiple sclerosis: for G.L. Mancardi, Genoa, Italy Bone marrow transplantation is a justifiable treatment for active relapsing remitting multiple sclerosis: against J.A. Cohen, Cleveland, United States Luigi Mancardi presented data to support HSCT. The ratesof efficacy are very good with...

Dimethly Fumarate delivers treatment to the brain

Based on Data presented by a company it was suggested that Dimethyl fumarate (dimethyl= two methyl [carbon and three hydrogens allowing the extra carbon bond to bind to something else] did not get in the CNS. If it did not do that how could it be neuroprotective and save nerves? Having given a few prods to address this I think it only fair to mention a poster which shows that monomethyl fumarate...

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