Education: Understand MS down the plug hole model of MS

Yesterday ,we described a model of MS presented to researchers, as a draining pond with lesions creating mini volcanoes.

This is based on recent article (click here)

To help us understand the pictures they gave us some videos too.

You may find them useful too.


In this
video depiction of
RRMS with early secondary
progressive disease, relapsing disease
transitions to SPMS with disability being driven in the early years by
relapse  (“base effects”) and in the
later years primarily by the declining threshold (“surface effects”).
Highly active RRMS

In this video depiction of RRMS,
highly active disease is characterized topographically by extensive clinical
and sub-clinical inflammatory activity. Several lesions in the spinal cord and
brainstem do not resolve below the clinical threshold, demonstrating lesions with high degree of severity and low capacity for
Mild RRMS with limited disability accumulation
In this video depiction of mild RRMS, no demonstrable disability is accumulated at 20 years of disease. All relapses resolve below the clinical threshold—demonstrating lesions with a high recovery capacity—and there is little depletion of functional reserve beyond that of normal aging.
In this video depiction of PPMS,
several sub-threshold lesions, denoting underlying disease activity, do not
cross the clinical threshold until functional reserve declines. Disability is
driven over time by the dropping threshold.

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  • Why is are there no "unhelpful", "very unhelpful" and "extremely unhelpful" boxes to check? This would be more scientific.

    • Because trolls used to spend all their time ticking unhelpful, so it seemed sensible to remove their fun as surely they have better things to do.

  • "A hypothesis driven biologically informed model could build on the clinical phenotypes to encompass the dynamic admixture of factors underlying MS disease course".

    Then according to the latest publications there is a different manifestation of MS even dependent on biological questions phenotype? And the T cells would respond to various antigens, which thereafter forward the same answer and that would cause what we know as MS?

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