HRT in post-menopausal women with MS

Neurology. 2016 Sep 7. pii: 10.1212/WNL.0000000000003176. [Epub ahead of print]

Hormone therapy use and physical quality of life in postmenopausal women with multiple sclerosis.


To determine the association between hormone therapy (HT) and physical quality of life (QOL) in postmenopausal women with multiple sclerosis (MS).


We included female participants from the prospective Nurses’ Health Study, with a diagnosis of definite or probable MS, who had completed a physical functioning assessment (PF10; subscale of the 36-Item Short-Form Health Survey QOL survey) at a time point between 3 and 10 years after their final menstrual period (early postmenopause). We assessed the association between HT use at this time point (never vs at least 12 months of systemic estrogen with/without progestin) and both PF10 and the 36-Item Short-Form Health Survey Physical Component Scale. We used a linear regression model adjusting for age, MS duration, menopause type and duration, and further for additional covariates (only ancestry was significant).


Among 95 participants meeting all inclusion criteria at their first postmenopausal assessment, 61 reported HT use and 34 reported none. HT users differed from non-HT users in MS duration (p = 0.02) and menopause type (p = 0.01) but no other clinical or demographic characteristics. HT users had average PF10 scores that were 23 points higher than non-HT users (adjusted p = 0.004) and average Physical Component Scale scores that were 9.1 points higher in the 59 women with these available (adjusted p = 0.02). Longer duration of HT use was also associated with higher PF10 scores (p = 0.02, adjusted p = 0.06).


Systemic HT use was associated with better physical QOL in postmenopausal women with MS in this observational study. Further studies are necessary to investigate causality.


Previously, I have posted on oral contraceptive use in MS:; but what of hormone replacement therapy (HRT) during the post-menopausal period?

The story with HRT is equally murky. There is data to support HRT use in the perimenopausal period (50-60y), with evidence of protection against cognitive aging (Rocca WA et al. Oophorectomy, menopause, estrogen treatment, and cognitive aging: clincal evidence for a window of opportunity. Brain Res 2011;1379:188–198; Bove R et al. Age at surgical menpause influences cognitive decline and Alzheimer pathology in older women. Neurology 2014;82:222–229). But concerns have been raised over an increased risk of stroke and cognitive decline in much older women >65y (Rapp SR et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women’s Health Initiative Memory Study: a randomized controlled trial. JAMA 2003;289:2663–2672).

In this study, Bove et al. report higher quality of life measures in the HRT group (~57y) than in the non-HRT group (~56y), with a greater HRT duration being associated with higher scores.

But, a note of caution, this is purely an observational study and does not establish a causal relationship. A randomised controlled trail is needed to do this. Given the safety concerns over HRT use, whether this is feasible remains to be seen.

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Neuro Doc Gnanapavan


  • Hormones is a conflicting issue even for me, more studies are needed to solve the dilemma about what the real role of hormones in those with MS…

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