ArchiveOctober 2016

B cells as antigen presenting cells.

Fraussen J, Claes N, Van Wijmeersch B, van Horssen J, Stinissen P, Hupperts R, Somers V. B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses. Clin Immunol. 2016 . pii: S1521-6616(16)30163-2 Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study, B cell antigen presentation and costimulation in MS...

Do nothing Lose teeth….Do Nothing Lose Brain..I can get falsies

Neurology is an odd subject because there are lots of conditions and not many treatments.  Therefore you can have a bright bod that can diagnose you…but then they can say “sorry we can’t do anything about it” In the bad old days this is what happened.  But this should not be the case with MS. This is because there are an increasing number of treatments that may offer benefit..at least...

Better reported trials

Rikos D, Dardiotis E, Tsivgoulis G, Zintzaras E, Hadjigeorgiou GM.Reporting quality of randomized-controlled trials in multiple sclerosis from 2000 to 2015, based on CONSORT statement.Mult Scler Relat Disord. 2016 Sep;9:135-139.BACKGROUND: Randomized controlled trials (RCTs) are the best tool to evaluate the effectiveness of clinical interventions. The CONSORT (Consolidated Standards of Reporting...

Needles, haystacks, and primary progressive MS: big data debunks big headlines

Our understanding of how genes influence disease is better than ever, and increasing at an incredible rate. While some diseases like Huntington’s disease are caused by mutations in a single gene, most diseases are influenced by a huge number of variants across the genome. Multiple sclerosis, diabetes, and cardiovascular disease are examples of conditions which are not caused by a single gene...

Exercise can’t be associated with reduced risk

Dorans KS, Massa J, Chitnis T, Ascherio A, Munger KL.Physical activity and the incidence of multiple sclerosis. Neurology. 2016 Sep 28. pii: 10.1212/WNL.0000000000003260. [Epub ahead of print] OBJECTIVE:To study whether physical activity during adulthood or early life is associated with multiple sclerosis (MS) incidence in 2 prospective cohorts of women.METHODS:Women in the Nurses’...

Stop Smoking

O’Gorman CM, Broadley SA. Smoking increases the risk of progression in multiple sclerosis: A cohort study in Queensland, Australia. J Neurol Sci. 2016 ;370:219-223. BACKGROUND:Cigarette smoking has been associated with increased risk of progressive multiple sclerosis (MS). The effect of smoking status on risk and timing of disease progression in patients with MS in Queensland, Australia has...

Cannabis controling spasticity

Squintani G, Donato F, Turri M, Deotto L, Teatini F, Moretto G, Erro R. Cortical and spinal excitability in patients with multiple sclerosis and spasticity after oromucosal cannabinoid spray. J Neurol Sci. 2016;370:263-268. doi: 10.1016/j.jns.2016.09.054. BACKGROUND: Delta-9-tetrahydrocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex®) has been recently approved for the...

JCV are we in safer times?

Acta Neurol Scand. 2016 Oct 20. doi: 10.1111/ane.12699. [Epub ahead of print] JCV serology in time: 3 years of follow-up. Cambron M, Hadhoum N, Duhin E, Lacour A, Chouraki A, Vermersch P. Abstract OBJECTIVES: Although many neurologists are reluctant to use natalizumab in MS (multiple sclerosis) given the increased risk for PML (progressive multifocal leukoencephalopathy), trust was regained with...

Getting the Right Models

Lassmann H, Bradl M.Multiple sclerosis: experimental models and reality. Acta Neuropathol. 2016 Oct 20. Review. One of the most frequent statements, provided in different variations in the introduction of experimental studies on multiple sclerosis(MS), is that “Multiple sclerosis is a demyelinating autoimmune disease and experimental autoimmune encephalomyelitis (EAE) is a suitable...

Alemtuzumab and the innate immune cells

Gross CC, Ahmetspahic D, Ruck T, Schulte-Mecklenbeck A, Schwarte K, Jörgens S, Scheu S, Windhagen S, Graefe B, Melzer N, Klotz L, Arolt V, Wiendl H, Meuth SG, Alferink J. Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Oct 12;3(6):e289. OBJECTIVE:To characterize changes in myeloid and lymphoid innate immune cells in...

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