The MS community has had its share of ‘post-truisms‘. The most recent that comes to mind is CCSVI. No matter how much the traditional ‘MS establishment‘ or ‘MS intelligentsia‘ spoke out against the concept of CCSVI the more a small, but very vocal, group that are now known as the CCSVIers were able to drown out the ‘truth‘.
Many years after the eye of the storm has passed the paper below comes out from the Canadian group showing that the prevalence of extracranial venous narrowing in pwMS is no different to that in siblings of pwMS and normal control subjects. It appears that these narrowings in the veins of pwMS are non-specific and therefore cannot be linked causally to MS. Will this be the last we hear of CCSVI? As a meme CCSVI, appears to have had its time in sun.
Similar in People With Multiple Sclerosis, Their Siblings, and Unrelated Healthy …. Canadian Association of …, 2016
Purpose: The study sought to assess and compare the prevalence of narrowing of the major extracranial veins in subjects with multiple sclerosis and controls, and to assess the sensitivity and specificity of magnetic resonance venography (MRV) for describing extracranial venous narrowing as it applies to the chronic cerebrospinal venous insufficiency theory, using catheter venography (CV) as the gold standard.
Methods: The jugular and azygos veins were assessed with time-of-flight MRV in this assessor-blinded, case-control study of subjects with multiple sclerosis, their unaffected siblings, and unrelated controls. The veins were evaluated by diameter and area, and compared with CV. Collateral vessels were also analyzed for maximal diameter, as a potential indicator of compensatory flow.