Kirkland MC, Downer MB, Holloway BJ, Wallack EM, Lockyer EJ, Buckle NC, Abbott CL, Ploughman M. Bipedal Hopping Reveals Evidence of Advanced Neuromuscular Aging Among People With Mild Multiple Sclerosis. J Mot Behav. 2016:1-9. Measures of walking such as the timed 25-ft walk test (T25FWT) may not be able to detect subtle impairment in lower limb function among people with multiple...
Fingol against Nataliziumab…and the Winner is….
A longitudinal real-life comparison study of natalizumab and fingolimod.Lanzillo R, Carotenuto A, Moccia M, Saccà F, Russo CV, Massarelli M, De Rosa A, Brescia Morra V.Acta Neurol Scand. 2016 Dec 15. doi: 10.1111/ane.12718. [Epub ahead of print] BACKGROUND:Different retrospective studies compared natalizumab and fingolimod in relapsing-remitting multiple sclerosis (RRMS), with conflicting results...
Gut flora making susceptibility
Stanisavljević S, Lukić J, Soković S, Mihajlovic S, Mostarica Stojković M, Miljković D, Golić N.Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. Front Microbiol. 2016;7:2005. doi: 10.3389/fmicb.2016.02005. Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that...
Dyeing to remember the good old stains
Sudan black: a fast, easy, and non-toxic method to assess myelin repair in demyelinating diseases.Ineichen BV, Weinmann O, Good N, Plattner P, Wicki C, Rushing EJ, Linnebank M, Schwab ME.Neuropathol Appl Neurobiol. 2016. doi: 10.1111/nan.12373. [Epub ahead of print]AIMS: The search for novel drugs that enhance myelin repair in entities such as multiple sclerosis has top priority in neurological...
Lesions revisited
An updated histological classification system for multiple sclerosis lesions. Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H. Acta Neuropathol. 2016 Dec 17. [Epub ahead of print] Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating disease of the central nervous system (CNS). Although a number of histological classification systems...
The search for the MS autoantigen – fools gold or a reality?
Sci Rep. 2016 Dec 23;6:39430. doi: 10.1038/srep39430. Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae. Walvoort MT, Testa C, Eilam R, Aharoni R, Nuti F, Rossi G, Real-Fernandez F, Lanzillo R, Brescia Morra V, Lolli F, Rovero P, Imperiali B, Papini AM. Abstract In autoimmune diseases, there have been proposals...
PML in Italy
Mouse Doctor is still away so I am adding a comment on this post for him. It is clear that the derisking of PML is working. When you pick-up PML in the asymptomatic phase PMLers do better. The real question is that with so many other options, and emerging treatment option, both on- and off-label, should we putting anyone at risk of developing PML unnecessarily? I would say no, but then I...
Bad Breath
Nakhleh MK, Amal H, Jeries R, Broza YY, Aboud M, Gharra A, Ivgi H, Khatib S, Badarneh S, Har-Shai L, Glass-Marmor L, Lejbkowicz I, Miller A, Badarny S, Winer R, Finberg J, Cohen-Kaminsky S, Perros F, Montani D, Girerd B, Garcia G, Simonneau G, Nakhoul F, Baram S, Salim R, Hakim M, Gruber M, Ronen O, Marshak T, Doweck I, Nativ O, Bahouth Z, Shi DY, Zhang W, Hua QL, Pan YY, Tao L, Liu H, Karban A...