ArchiveDecember 2016

Will the Kangeroo Test supercede the 25 foot walk to measure outcomes?

Kirkland MC, Downer MB, Holloway BJ, Wallack EM, Lockyer EJ, Buckle NC, Abbott CL, Ploughman M. Bipedal Hopping Reveals Evidence of Advanced Neuromuscular Aging Among People With Mild Multiple Sclerosis. J Mot Behav. 2016:1-9. Measures of walking such as the timed 25-ft walk test (T25FWT) may not be able to detect subtle impairment in lower limb function among people with multiple...

#HappyNewYear: a better understanding of progressive MS

MS is #1-disease-not-2-or-3-diseases – #HappyNewYear One of your wishes for 2017 is ‘a better understanding of progressive MS. I would love an explanation of why MS morphs from RR to SP‘. I have tried many times to explain this in plain English. The following is an updated version of a previous post that I wrote more than a year ago in response to a statement by Steve Hauser...

Fingol against Nataliziumab…and the Winner is….

A longitudinal real-life comparison study of natalizumab and fingolimod.Lanzillo R, Carotenuto A, Moccia M, Saccà F, Russo CV, Massarelli M, De Rosa A, Brescia Morra V.Acta Neurol Scand. 2016 Dec 15. doi: 10.1111/ane.12718. [Epub ahead of print] BACKGROUND:Different retrospective studies compared natalizumab and fingolimod in relapsing-remitting multiple sclerosis (RRMS), with conflicting results...

Gut flora making susceptibility

Stanisavljević S, Lukić J, Soković S, Mihajlovic S, Mostarica Stojković M, Miljković D, Golić N.Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. Front Microbiol. 2016;7:2005. doi: 10.3389/fmicb.2016.02005. Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that...

#ResearchSpeak: depression in MS is associated with focal brain damage

Would you be surprised if I told you that the black dog is associated with structural changes in the brains of pwMS? #ResearchSpeak #MSBlog The smallish study below shows that depressive symptoms in pwMS is associated with gray matter loss in the left temporal lobe. The implication is that damage in the neuronal pathways that are linked to this particular area of the brain is associated with...

#CaseStudy: off-label DMTs are not a panacea

How do we treat active PPMS whilst we wait for ocrelizumab? #CaseStudy #MSBlog #ClinicSpeak This post is a follow-on from two preceding posts on a #CaseStudy of someone with active PPMS. You may want to read the prior posts and the relevant comments before proceeding with this post.  #CaseStudy PPMS: post 1, 19 December 2016 #CaseStudy PPMS: post 2, 21 December 2016 I note that many of you...

Dyeing to remember the good old stains

Sudan black: a fast, easy, and non-toxic method to assess myelin repair in demyelinating diseases.Ineichen BV, Weinmann O, Good N, Plattner P, Wicki C, Rushing EJ, Linnebank M, Schwab ME.Neuropathol Appl Neurobiol. 2016. doi: 10.1111/nan.12373. [Epub ahead of print]AIMS: The search for novel drugs that enhance myelin repair in entities such as multiple sclerosis has top priority in neurological...

#ClinicSpeak & #ResearchSpeak: causes of death in MS

Tis the season to consider life and the end-of-life; have you thought about yours? #ClinicSpeak #ResearchSpeak #MSBlog  What awaits me at the end? The following Austrian study on the autopsies of 10 people with MS who were critically ill, i.e. who needed to be admitted to an ITU, and died and came to autopsy, tries to answer the question. All these individuals had longstanding MS and had...

Lesions revisited

An updated histological classification system for multiple sclerosis lesions. Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H. Acta Neuropathol. 2016 Dec 17. [Epub ahead of print] Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating disease of the central nervous system (CNS). Although a number of histological classification systems...

The search for the MS autoantigen – fools gold or a reality?

Sci Rep. 2016 Dec 23;6:39430. doi: 10.1038/srep39430. Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae. Walvoort MT, Testa C, Eilam R, Aharoni R, Nuti F, Rossi G, Real-Fernandez F, Lanzillo R, Brescia Morra V, Lolli F, Rovero P, Imperiali B, Papini AM. Abstract In autoimmune diseases, there have been proposals...

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