ArchiveDecember 2016

PML in Italy

Mouse Doctor is still away so I am adding a comment on this post for him.  It is clear that the derisking of PML is working. When you pick-up PML in the asymptomatic phase PMLers do better. The real question is that with so many other options, and emerging treatment option, both on- and off-label, should we putting anyone at risk of developing PML unnecessarily? I would say no, but then I...

Bad Breath

Nakhleh MK, Amal H, Jeries R, Broza YY, Aboud M, Gharra A, Ivgi H, Khatib S, Badarneh S, Har-Shai L, Glass-Marmor L, Lejbkowicz I, Miller A, Badarny S, Winer R, Finberg J, Cohen-Kaminsky S, Perros F, Montani D, Girerd B, Garcia G, Simonneau G, Nakhoul F, Baram S, Salim R, Hakim M, Gruber M, Ronen O, Marshak T, Doweck I, Nativ O, Bahouth Z, Shi DY, Zhang W, Hua QL, Pan YY, Tao L, Liu H, Karban A...

#ClinicSpeak: no wonder MSers have such a hard time in society

Subtle cognitive deficits in MS may underlie how MSers interact with society. #ClinicSpeak #ResearchSpeak #BartsMS Definition: Empathy is the capacity to understand or feel what another person is experiencing from within the other being’s frame of reference, i.e., the capacity to place oneself in another’s position. Empathy is seeing with the eyes of another, listening with the ears...

#ThinkSpeak: Do you have any wishes for 2017?

Any MS ideas and suggestions for 2017? #ThinkSpeak #BartsMS #MSBlog My ‘holidays‘ started last night. We had dinner with a very good friend from my clinical firm in medical school. Her son has just graduated from Wits medical school in Johannesburg. This is 29 years after we graduated; where has the time gone? We all agreed that 2016 was an annus horribilis; I have never felt so...

What is a neutralizing response?

Bachelet D, Hässler S, Mbogning C, Link J, Ryner M, Ramanujam R, Auer M, Hyldgaard Jensen PE, Koch-Henriksen N, Warnke C, Ingenhoven K, Buck D, Grummel V, Lawton A, Donnellan N, Hincelin-Mery A, Sikkema D, Pallardy M, Kieseier B, Hemmer B, Hartung HP, Soelberg Sorensen P, Deisenhammer F, Dönnes P, Davidson J, Fogdell-Hahn A, Broët P; ABIRISK Consortium.. Occurrence of Anti-Drug...

#ResearchSpeak: how does B-cell depletion therapy work in MS?

Can old news be good news? Yes, people with PPMS now have hope. #ResearchNews #MSBlog The ocrelizumab in PPMS and RRMS studies were published yesterday. Although the results are old news, having been presented on this blog many times, their publication is good news. Peer-review publications are still the academic gold-standard.  The clock is ticking and I sincerely hope, and expect, both the...

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