ArchiveJanuary 2017

Not so Silent Lesions. Will the Real Progressive MS stand Up.

Wundes A, Bowen JD, Kraft GH, Maravilla KR, McLaughlin B, von Geldern G, Georges G, Nash RA, Lu JQ. Brain pathology of a patient 7 years after autologous hematopoietic stem cell transplantation for multiple sclerosis. J Neurol Sci. 2017 ;373:339-341.  Aggressive immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) can be an effective...

The silent MS lesions

Exp Ther Med. 2017 Jan;13(1):91-96. doi: 10.3892/etm.2016.3950. Epub 2016 Dec 2. Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis. Chen J, Zhou C, Zhu L, Yan X, Wang Y, Chen X, Fang S. Abstract It remains challenging to locate occult lesions in patients with multiple sclerosis (MS). Diffusion tensor imaging (DTI) has been demonstrated to have the...

Rebound? What causes the emergence of disease after alemtuzumab

#MS Research #Clinical Speak There was a report of severe disease activity that occured within 6 months of the first infusion of alemtuzumab.This responded to B cell depletion. The first suggestion was this could be a novel CNS autoimmunity, as could occur as discussed by Profg yesterday However could it be disease reactivation? This created some contradicting ideas (see post and comments) from...

Worsening after alemtuzumab

#MSresearch #Clinicspeak Haghikia A, Dendrou CA, Schneider R, Grüter T, Postert T, Matzke M, Stephanik H, Fugger L, Gold R. Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy. Lancet Neurol. 2017;16: 104-106. We have recently had reports suggesting that people taking alemtuzumab after fingolimod may be at increased risk of treatment failure. Bad news for alemtuzumab In...

All Antibodies are the same- think again!

New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies.Robak T, Robak E. BioDrugs. 2011;25:13-25. Over the last few years, new generations of anti-CD20 monoclonal antibodies (mAbs) have been developed for potential benefits over the classical, first-generation mAb rituximab. Compared with rituximab, new mAbs have enhanced antitumor activity resulting from increased...

The Dre Approach to treating RR MS

Sawad AB, Seoane-Vazquez E, Rodriguez-Monguio R, Turkistani F. Cost-effectiveness of different strategies for treatment relapsing-remitting multiple sclerosis. J Comp Eff Res. 2017 . doi: 10.2217/cer-2016-0056. [Epub ahead of print] AIM:To compare the cost-effectiveness of different disease-modifying therapies’ strategies for treatment of relapsing-remitting multiple sclerosis...

Biogen Skinned by a Patent Troll

Pharma don’t always get their way and when there is money to be made the vultures are out. It is reported (click) that Biogen has agreed to pay $1.25 billion in cash to Forward Pharma a Copenhagen-based firm that has no approved products. The legal battle centers on Biogen’s multiple sclerosis treatment Tecfidera, which raked in $4 billion in 2016 sales. Forward Pharma has been...

Cholesterol makes myelin…should we be eating bad fat.

Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.Nat Commun. 2017 Jan 24;8:14241. doi: 10.1038/ncomms14241. Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination...

Is ProfG making us go fishing?

ProfG’s highlight of the month in MSARDS                was EAE in Zebra fish (click here for a free copy)                                   I thought I would add more            There’s a video of EAE in fish….not for the...

Angry Astrocytes kill nerves and probably contribute to progressive MS

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA.Neurotoxic reactive astrocytes are induced by activated microglia.Nature. 2017. doi: 10.1038/nature21029. Reactive astrocytes are strongly induced by central...

Translate

Categories

Recent Posts

Recent Comments

Archives