ArchiveJanuary 2017

Winter sales…..increase profits.

In the UK, January used to be known for its sales, to encourage people to part with abit more cash after chrimbo.  However as Christmas now seems to begin in Septemebr/October the sales are on before christmas. January in MS world is also a time for sales…but it seems it is increasing sales…….as the companies eek out abit more profit. In this exert from the MS News website...

Your nose is the scenter of your face

PLoS One. 2017 Jan 20;12(1):e0170492. doi: 10.1371/journal.pone.0170492. eCollection 2017. Longitudinal Testing of Olfactory and Gustatory Function in Patients with Multiple Sclerosis. Uecker FC, Olze H, Kunte H, Gerz C, Göktas Ö, Harms L, Schmidt FA BACKGROUND: The aim of the study was to investigate changes of the olfactory and gustatory capacity in patients with multiple sclerosis (MS)...

Understarters Orders…whats the plan to ensure the race ends in a good outcome

This weekend’s post about alemtuzumab not working in some people after fingolimod begs the question “How we should transition people from fingolimod onto something else?” We have had this debate about natalizumab already. Look for the posts on this aspect. HIGHLIGHT Fingolimod and Natalizumab are “racehorse” drugs They keep cells trapped to stop them entering the...

Bullet Points to explain something important for people on fingolimod

Willis M, Pearson O, Illes Z, Sejbaek T, Nielsen C, Duddy M, Petheram K, van Munster C, Killestein J, Malmeström C, Tallantyre E, Robertson N. An observational study of alemtuzumab following fingolimod for multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2017 Jan 10;4(2):e320. Yesterday the “Headmaster” complained my post was too complicated. So maybe we should just do...

Thou shall have a fishy on a little dishy, thou shall have a fishy when the 3Rs boats come in

Kulkarni P, Yellanki S, Medishetti R, Sriram D, Saxena U, Yogeeswari P. Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis. Mult Scler Relat Disord. 2017 Jan;11:32-39. doi: 10.1016/j.msard.2016.11.010. INTRODUCTION: Pre-clinical drug discovery for multiple sclerosis (MS) is a labor intensive activity to perform in rodent models. This is owing to the long duration...

Fingolimod blocking Alemtuzumab action what does it tell us about MS?

Willis M, Pearson O, Illes Z, Sejbaek T, Nielsen C, Duddy M, Petheram K, van Munster C, Killestein J, Malmeström C, Tallantyre E, Robertson N. An observational study of alemtuzumab following fingolimod for multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2017 Jan 10;4(2):e320. OBJECTIVE:To describe a series of patients with relapsing multiple sclerosis (MS) who experienced significant and...

The tip of the iceberg?

It has been suggested that some people with Multiple Sclerosis have subtle evidence of disease activity long before they develop clinically-definite disease. The argument goes that if you performed detailed examinations and investigations, you would detect these subtle abnormalities in certain people before they meet diagnostic criteria for MS. In fact, according to one estimate, about...

GA…Today’s mechanism.

Ahn YH, Jeon SB, Chang CY, Goh EA, Kim SS, Kim HJ, Song J, Park EJ.Glatiramer acetate attenuates the activation of CD4+ T cells by modulating STAT1 and -3 signaling in glia.Sci Rep. 2017 Jan 17;7:40484 Interactions between immune effector cells of the central nervous system appear to directly or indirectly influence the progress/regression of multiple sclerosis (MS). Here, we report that glial...

Irish Medical Pot……You Will You Will You Will.

Crowley D, Collins C, Delargy I, Laird E, Van Hout MC. Irish general practitioner attitudes toward decriminalisation and medical use of cannabis: results from a national survey. Harm Reduct J. 2017; 14(1):4. doi: 10.1186/s12954-016-0129-7. BACKGROUND: Governmental debate in Ireland on the de facto decriminalisation of cannabis and legalisation for medical use is ongoing. A cannabis...

Digesting Science in Bournemouth

I had the great pleasure of travelling to Bournemouth last weekend to help the Dorset MS Service deliver a Digesting Science event for their families. The event was held in the incredibly well kitted out MS Society Osborne Centre in local West Parley. I was very impressed at the facilities in this centre and the programme of events that the branch runs to support people with and...

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