Jiang H et al. Amelioration of experimental autoimmune encephalomyelitis through transplantation of placental derived mesenchymal stem cells.Sci Rep 2017 Feb 10;7:41837. doi: 10.1038/srep41837.
Placental derived mesenchymal stem cells (PMSCs) have been suggested as a possible source of cells to treat multiple sclerosis (MS) due to their immunomodulatory functions, lack of ethical concerns, and potential to differentiate into neurons and oligodendrocytes. To investigate whether PMSCs share similar characteristics with embryonic mesenchymal stem cells (EMSCs), and if transplanted PMSCs have the ability to integrate and replace degenerated neural cells, we transplanted rat PMSCs and EMSCs into the central nervous system (CNS) of Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Our findings demonstrated that transplanted PMSCs, similar to EMSCs, were effective in decreasing infiltrating inflammatory cells, preserving axons, and ameliorating demyelination, thereby improving the neurological functions of animals. Moreover, both PMSCs and EMSCs had the ability to migrate into inflamed tissues and express neural-glial lineage markers. These findings suggest that PMSCs may replace EMSCs as a source of cells in MS stem cell therapy.
The blog is a site that allows us to talk about research, and some of it is good news and some is bad news. We hope some of the readers are scientists and neurologists as we feel it has educational content for all..but also we need to educate the public about the type of things scientists do.
We can do the rose-coloured tinted glasses approach, which you get in most Science websites where every thing is great. But if every thing was great, we would have cured something by now.
As a card carrying vivisectionist, we have to take the flank from parts of Society that do not like or want animal experiments. However, the UK Government want us to be open about working with animals, and this is why we post on animal studies.
I have decided against doing “cure of the week” which happens every week as I realize many animal studies are years away from offering something of use.
Anyway back to the post
If you poll pwMS about where we should be putting their research resources?. I bet high on the list will be people wanting stem cell trials.
This is because science has promised that we can reverse the effects of time, and the media and public have bought into this view, so you rightly say trials, trials, trials!
Indeed the MS Societies listen and put their resource behind their members wishes. Trials have been initiated and everybody’s hopes are high. The hope you are being sold is that the stems cells turn into myelinating cells and new nerves and then we can turn back time.
Everyone gets on the band wagon, and even we dipped our toe in the stem-cell waters.
I know you like to hear about this stuff, but I need to put this into perspective, because if the stem cells trials don’t work you will be blaming the animals…..Don’t!
So to describe the paper in this study creates mesencyhmal stem cells from embryos and placenta and show that they inhibit EAE and stop demyelination and nerve loss when transplanted into the brain.
Yeah we say.
However, how many more of these studies are we going to see?
I wonder whether we should call time?
The benefit is a small diminution, and sometimes a delay, due to a small inhibitory effect. Perhaps much of the benefit of demyelination and nerve loss reported can be then be downstream of this, because the damaging inflammatory response has not arrived in the CNS to cause damage.
I maintain that we need to see this data.
If all they really do is have an immunosuppressive action then is this the way to go?.
Remember this is an opinion and I could be wrong.
Am I wrong to be a cynic? and burst some bubbles or should I have a rant and say “Not in my name”
In the experiment above, there is a group where experiment healthy animals are followed and show nothing. They, are sometimes injected with adjuvants that serve essentially no useful function excepts it wastes animals. It is no longer an experiment, we know it is not going to induce neurological signs…stop it!
I personally refuse to accept this work if they do use injection in feet, it is bad science.This is the way to make people change practise..maybe not they just hide things:-).
It is obvious there are some people that do not care about this and they are based in prominent countries that should know better!
Yes, EAE will eventually end up there, but if we continue to undertake bad practices then we will hasten this process and so a good reason to speak out…the animals can’t
However, killing off animal work in the UK is going to mean that you get more of this guff.
Some people out there will be saying shut you whining minnie,