ArchiveMarch 2017

Defective T cell control of EBV in MS

Pender MP, Csurhes PA, Burrows JM, Burrows SR. Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.Clin Transl Immunology. 2017;6(1):e126. Mounting evidence indicates that infection with Epstein-Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV-infected B cells by CD8+ T cells might cause MS by allowing...

#NeuroSpeak & #ClinicSpeak: stability of the anti-JC virus antibody index

Interpreting the anti-JCV antibody index is more complicated than you think. #NeuroSpeak #ClinicSpeak PML seems to raise its ugly head whenever a new MS therapy emerges. A large number of us have gotten used to using JCV serostatus as risk mitigation tool. We use positvie or negative JCV serostatus to assess whether or not our patients are infected with the virus. If they are JCV seropositive we...

#NeuroSpeak: MS MasterClass for learning about managing MS

There are still a few places left on our next MS MasterClass #MSBlog #NeuroSpeak I chair the Multiple Sclerosis Academy with the specific aim of training neurology specialist registrars and non-specialist neurologists to manage MS. If you are interested in joining the Academy and attending the MasterClass please register your interest via this LINK. The feedback from our first...

#NewsSpeak: an eagle called ocrelizumab has landed

FDA licenses ocrelizumab for both relapsing and primary progressive forms of MS. #MSBlog #NewsSpeak #Ocrelizumab Yesterday was a pretty momentous day for people with MS (pwMS). The FDA licensed ocrelizumab for people with PPMS. The killjoys amongst you will say ‘What? The efficacy of ocrelizumab is so small in PPMS that it won’t make a difference’. My response to them would be...

A BAT associated with MS suceptibility

Our number one viewed post is how cats are associated with MS susceptibility, this new study links a BAT to MS susceptibility Galarza-Muñoz G, Briggs FB, Evsyukova I, Schott-Lerner G, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, Ko DC, Bradrick SS, Barcellos LF, Gregory SG, Garcia-Blanco MA. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple...

#ClinicSpeak & #ResearchSpeak: community integration

How integrated are you in your community? How has MS affected you socially? #ClinicSpeak #MSBlog #MSResearch I know I am stuck record, but part of the reason why this blog exists is to tell it how it is. We all know MS is a disabling disease and is associated with loss of quality of life. Social isolation is massive problem in MS; it gets worse with increasing disability and is associated with...

End of year round-up may end on a good note for Biogen

Eur J Neurol. 2017 Mar 22. doi: 10.1111/ene.13272. [Epub ahead of print] Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing-remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies. Havrdova E, Giovannoni G, Gold R, Fox RJ, Kappos L, Phillips JT, Okwuokenye M7, Marantz JL. Abstract BACKGROUND AND PURPOSE: Significant...

#ResearchSpeak: fools rush in where angels fear to tread

AHSCT for children with MS; do the benefits justify the risks? #MSBlog #ResearchSpeak  Some critics would state that resorting to HSCT to control MS in children is foolish. However, life sometimes rewards the brave. The paper below describes the use of autologous hematopoietic stem cell transplantation (aHSCT) in children with MS. They describe 21 children with MS from across Europe who...

#ClinicSpeak & NeuroSpeak: MS drugs and your mouth

How common are oral side effect in pwMS on medication? #ClinicSpeak #NeuroSpeak #MSBlog Most pwMS are on poly-pharmacy (multiple prescribed medications) both DMTs and symptomatic treatments. The review article below highlights the problem. It identified 18 oral side effects with dryness of the mouth (xerostomia) being the most common, followed by abnormal taste (dysgeusia), difficulty...

The New Publication Paradigm..Money down the toilet

Historically we would publish our papers in scientific journals. We would donate our work for free and sometimes even pay a page charge to do this. We would assign copyright to the publishers. They may give you 50-100 reprints for free to give away. Librabries would take a subscription to the journals and academics could get access to the journals via their library. The Internet occurred and...

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