ArchiveMarch 2017

Defective T cell control of EBV in MS

Pender MP, Csurhes PA, Burrows JM, Burrows SR. Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.Clin Transl Immunology. 2017;6(1):e126. Mounting evidence indicates that infection with Epstein-Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV-infected B cells by CD8+ T cells might cause MS by allowing...

A BAT associated with MS suceptibility

Our number one viewed post is how cats are associated with MS susceptibility, this new study links a BAT to MS susceptibility Galarza-Muñoz G, Briggs FB, Evsyukova I, Schott-Lerner G, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, Ko DC, Bradrick SS, Barcellos LF, Gregory SG, Garcia-Blanco MA. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple...

End of year round-up may end on a good note for Biogen

Eur J Neurol. 2017 Mar 22. doi: 10.1111/ene.13272. [Epub ahead of print] Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing-remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies. Havrdova E, Giovannoni G, Gold R, Fox RJ, Kappos L, Phillips JT, Okwuokenye M7, Marantz JL. Abstract BACKGROUND AND PURPOSE: Significant...

The New Publication Paradigm..Money down the toilet

Historically we would publish our papers in scientific journals. We would donate our work for free and sometimes even pay a page charge to do this. We would assign copyright to the publishers. They may give you 50-100 reprints for free to give away. Librabries would take a subscription to the journals and academics could get access to the journals via their library. The Internet occurred and...

MS lymphocytes making new myelin

Adaptive human immunity drives remyelination in a mouse model of demyelination. El Behi M, Sanson C, Bachelin C, Guillot-Noël L, Fransson J, Stankoff B, Maillart E, Sarrazin N, Guillemot V, Abdi H, Cournu-Rebeix I, Fontaine B, Zujovic V. Brain. 2017. doi: 10.1093/brain/awx008. [Epub ahead of print] One major challenge in multiple sclerosis is to understand the cellular and molecular...

More on B cells.We don’t all have the same ideas. Who is right?

We don’t normally report on reviews. But we have a couple of recent ones Nguyen AL, Gresle M, Marshall T, Butzkueven H, Field J. “Monoclonal antibodies in the treatment of MS: emergence of B-cell targeted therapies”. Br J Pharmacol. 2017 Mar 20. doi: 10.1111/bph.13780. [Epub ahead of print] Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most...

Do Mice Have Paws? What have they got?

We have been requesting access to data from pharma relating to B cells and disease activity.  As we told you, we got kicked back by some of the Companies,  This prompted ProfG to start a petition to ask  Ely Lilly to release their anti-B cell in MS trial data  (Click here to sign) One of the bloggers to say the least was very angry at this and wrote “MD. I’ve...

Natural Killer cells and MS

Natural killer cell subpopulations are associated with MRI activity in a relapsing-remitting multiple sclerosis patient cohort from Australia.Caruana P, Lemmert K, Ribbons K, Lea R, Lechner-Scott J. Mult Scler. 2016:1352458516679267. doi: 10.1177/1352458516679267 To examine NK subsets in MS patients on different treatments and to evaluate the role of NK subsets as indicators for disease activity...

Imaging hot microglia.

Datta G, Colasanti A, Kalk N, Owen DR, Scott G, Rabiner EI, Gunn R, Lingford-Hughes A, Malik O, Ciccarelli O, Nicholas R, Nie L, Battaglini M, De Stefano N, Matthews P. [11C]PBR28 or [18F]PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis.J Nucl Med. 2017. pii: jnumed.116.187161. doi: 10.2967/jnumed.116.187161. [Epub ahead of print] Objective: To assess microglial...

#DigestingScience at Great Ormond Street hospital

On Saturday we were at Great Ormond Street to take part in their educational day for families affected by demyelinating conditions. Although the Digesting Science activities were originally designed to teach children aged 6 – 12 about their parents MS, they can also teach children about their own condition. The morning was really inspiring and we met some amazing young people with a good...

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