ArchiveMarch 2017

Don’t write off a write-off: a reassessment of Teriflunomide

Mult Scler. 2017 Mar 1:1352458517695468. doi: 10.1177/1352458517695468. [Epub ahead of print] The efficacy of teriflunomide in patients who received prior disease-modifying treatments: Subgroup analyses of the teriflunomide phase 3 TEMSO and TOWER studies. Freedman MS, Wolinsky JS, Comi G, Kappos L, Olsson TP, Miller AE, Thangavelu K, Benamor M, Truffinet P, O’Connor PW; TEMSO and TOWER...

What Did the B Cell Video Miss?

Many Years (1994) Ago,  I made an (immortalised) B cell Line.  Here are the Pictures (low power on left).   On cell surface (on the right) there are little blobs.  What were they? They were Budding Virus Particles So Maybe the New B cell Video didn’t miss a trick.  Here’s the B cell containing Little blobs too. They get infected with Virus in...

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J...

Predicting MS Activity

Neurofilament light chain in cerebrospinal fluid and prediction of disease activity in clinically isolated syndrome and relapsing-remitting multiple sclerosis. Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.Eur J Neurol. 2017 . doi: 10.1111/ene.13274. [Epub ahead of print] BACKGROUND AND PURPOSE: Improved biomarkers are needed to...

Viral Infections can be a problem

Clerico M, De Mercanti S, Artusi CA, Durelli L, Naismith RT. Active CMV infection in two patients with multiple sclerosis treated with alemtuzumab. Mult Scler. 2017 Feb 1:1352458516688350. doi: 10.1177/1352458516688350. [Epub ahead of print] Alemtuzumab is a humanized monoclonal antibody targeting the surface molecule CD52, resulting in a rapid depletion of innate and adaptive immune cells...

Size matters

Cortese M, Riise T, Bjørnevik K, Myhr KM; Multiple Sclerosis Conscript Service Database Study Group. Body size and physical exercise, and the risk of multiple sclerosis. Mult Scler. 2017: 1352458517699289 BACKGROUND: Whether large body size increases multiple sclerosis (MS) risk in men is not well understood. Concurrently, physical exercise could be an independent protective factor...

Monitoring Memory B cell Number to keep Efficacy and Increase Safety

Grant Ideas for Free Monthly In this issue, I have predicted that this will be the year of the B cell, as I expect ocrelizumab to get a licence for the treatment of relapsing MS, or perhaps even active (relapsing & progressive) MS. We have got the year off to a flying B cell start with our recent paper, which shifts the focus from the T cell onto the B cell and notably the memory B cell...

Season of Birth Effect….in Mice

Reynolds JD, Case LK, Krementsov DN, Raza A, Bartiss R, Teuscher C. Modeling month-season of birth as a risk factor in mouse models of chronic disease: from multiple sclerosis to autoimmune encephalomyelitis. FASEB J. 2017. pii: fj.201700062. doi: 10.1096/fj.201700062. [Epub ahead of print] Month-season of birth (M-SOB) is a risk factor in multiple chronic diseases, including multiple...

Team G review for Progressive MS points the way to success for progressive MS

Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses. Giovannoni G, Cutter G, Pia-Sormani M, Belachew S, Hyde R, Koendgen H, Knappertz V, Tomic D, Leppert D, Herndon R, Wheeler-Kingshott CA, Ciccarelli O, Selwood D, di Cantogno EV, Ben-Amor AF, Matthews P, Carassiti D, Baker D, Schmierer K. Mult Scler Relat...

Sniffing salt water the next big treatment?

Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy.Mondal S, Rangasamy SB, Ghosh S, Watson RL, Pahan K.Neurochem Res. 2017 Mar 7. doi: 10.1007/s11064-017-2214-z. [Epub ahead of print] Developing a new and effective therapeutic approach against multiple sclerosis (MS)...

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