ArchiveMarch 2017

#CarerSpeak & #ClinicSpeak: child carers

Austerity Britain and the army of child carers. What should we do? #ClinicSpeak #MSBlog #CarerSpeak #CarerSpeak is the new label or #tag for posts of direct relevance to MS carers “Dear Professor Giovannoni, Can you help? I am 14 and I care for my Mum. Her multiple sclerosis is getting worse and I now have to spend most of my time looking after her. I have to prepare her tablets for...

MS lymphocytes making new myelin

Adaptive human immunity drives remyelination in a mouse model of demyelination. El Behi M, Sanson C, Bachelin C, Guillot-Noël L, Fransson J, Stankoff B, Maillart E, Sarrazin N, Guillemot V, Abdi H, Cournu-Rebeix I, Fontaine B, Zujovic V. Brain. 2017. doi: 10.1093/brain/awx008. [Epub ahead of print] One major challenge in multiple sclerosis is to understand the cellular and molecular...

#PoliticalSpeak: impact or lack of impact

Why has academia become so bureaucratic? #PoliticalSpeak #MSBlog Life as an academic is becoming increasingly complicated and frustrating; I spend an extraordinary amount of time doing administration. We have been asked to start preparing for the next REF, which is likely to be in 2020, and need your help.  In the UK academic institutions are assessed every 6-7 years as part of the Research...

More on B cells.We don’t all have the same ideas. Who is right?

We don’t normally report on reviews. But we have a couple of recent ones Nguyen AL, Gresle M, Marshall T, Butzkueven H, Field J. “Monoclonal antibodies in the treatment of MS: emergence of B-cell targeted therapies”. Br J Pharmacol. 2017 Mar 20. doi: 10.1111/bph.13780. [Epub ahead of print] Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most...

Do Mice Have Paws? What have they got?

We have been requesting access to data from pharma relating to B cells and disease activity.  As we told you, we got kicked back by some of the Companies,  This prompted ProfG to start a petition to ask  Ely Lilly to release their anti-B cell in MS trial data  (Click here to sign) One of the bloggers to say the least was very angry at this and wrote “MD. I’ve...

Natural Killer cells and MS

Natural killer cell subpopulations are associated with MRI activity in a relapsing-remitting multiple sclerosis patient cohort from Australia.Caruana P, Lemmert K, Ribbons K, Lea R, Lechner-Scott J. Mult Scler. 2016:1352458516679267. doi: 10.1177/1352458516679267 To examine NK subsets in MS patients on different treatments and to evaluate the role of NK subsets as indicators for disease activity...

#PoliticalSpeak & #OffLabel: it is okay to use off-label DMTs

Off-label prescribing; how do we get it adopted? #PoliticalSpeak #MSBlog #OffLabel My number one book from my homeland, South Africa.  ‘Who knows for what we live, and struggle, and die? Wise men write many books, in words too hard to understand. But this, the purpose of our lives, the end of all our struggle, is beyond all human wisdom.’ ‘You ask yourself not if this or...

ClinicSpeak; gardening post-alemtuzumab

Another opportunistic infection associated with alemtuzumab use in a person with MS. #MSBlog #ClinicSpeak Question: “I am day 12 day after last alemtuzumab dose and probably have lymphopenia/leukopenia at the moment. Should I avoid the garden this spring :-(?” Answer: Yes, you are putting yourself at risk of Nocardial infection. Nocardia species live in the soil. There have been cases...

#ClinicSpeak & #Neurospeak: low platelets with alemtuzumab

Not all low platelet counts post-alemtuzumab are due to ITP. #ClinicSpeak #NeuroSpeak #MSBlog I received a query from a colleague a few months ago about a low platelet count in one their patients treated with alemtuzumab. The low platelet count was in the first week, it was transient and was not due to ITP. We became aware of this a few years ago and dropped Professor Coles an email about the...

Imaging hot microglia.

Datta G, Colasanti A, Kalk N, Owen DR, Scott G, Rabiner EI, Gunn R, Lingford-Hughes A, Malik O, Ciccarelli O, Nicholas R, Nie L, Battaglini M, De Stefano N, Matthews P. [11C]PBR28 or [18F]PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis.J Nucl Med. 2017. pii: jnumed.116.187161. doi: 10.2967/jnumed.116.187161. [Epub ahead of print] Objective: To assess microglial...

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