ArchiveApril 2017

HSCT appears more effective than current MS drugs

Sormani MP, Muraro PA, Schiavetti I, Signori A, Laroni A, Saccardi R, Mancardi GL. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A meta-analysis.Neurology. 2017 Apr 28. pii: 10.1212/WNL.0000000000003987. doi: 10.1212/WNL.0000000000003987. [Epub ahead of print] OBJECTIVE:To summarize the evidence on immunoablative therapy followed by autologous hematopoietic stem cell...

AAN News A Trial Too Short…ASCEND raises the view that Nataizumab really did work in Progressive MS

ASCEND Phase 3 Trial Open-Label Extension Study Results: Natalizumab May Delay Disability Progression in Secondary Progressive Multiple Sclerosis (SPMS)  Hans-Peter Hartung , Douglas Arnold, Mark Freedman , Eva Havrdova , Douglas Jeffery , Raju Kapoor , Aaron Miller , Finn Sellebjerg , Haihong Li, Nisha Lucas, Diego Cadavid, Nolan Campbell, Pei-Ran Ho, Deborah Steiner Objective: To...

The Young Ones: Bringing Digesting Science to young carers

#DigestingScience #Youngcarers #MS #multiplesclerosis Digesting Science is an event where 6-12 year olds engage in fun activities, to learn more about MS. It’s aimed at children who have a parent (or parents, or carers) with MS. Over half a day, families complete games and challenges to learn more about the risk factors, symptoms, treatments and science behind the condition. The activities were...

Mosquitos leads us to more evidence for the memory B cells at centre stage for the causal pathway to MS.

In the week that began with a bit of Fake News about the cause of MS, and it ends with something that is perhaps related to the cause,  but two “Cause” stories in a Week are not going to make it in the News.  Why do I say cause, because this is Genetics and this is the predisposition of Risk. So what have B cells got to do with Mosquitos? Read on Overexpression of the...

MS is now a Kidney Disease :-)

Zhou X, Packialakshmi B, Xiao Y, Nurmukhambetova S, Lees JR. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet.Cell Immunol. 2017 Apr 18. pii: S0008-8749(17)30062-X.  Recent demonstrations of exacerbation of experimental autoimmune encephalomyelitis (EAE) by high salt...

#ThinkSpeak & #ClinicSpeak: blog links

Can you please let us know which web links you want us to support? #ThinkSpeak #ClinicSpeak During the AAN a neurologist from the US came up to me and thanked me for our blog and said that it had become his go to resource for information and that he used our landing page for all other MS resources. He specifically asked me to put back our PML infographic and other web links. Do others feel this...

Cause of multiple sclerosis

As all is quiet on the MS News and twitter front, so I will not rush a post out today. You can have it tomorrow. However, whilst MS awareness week started with a media-bang of the “Discovery of the cause of MS”, science emerged yesterday of something that actually contributes to the cause of MS, but has gone largely un-noticed by the media so far.  Two stories on the cause of MS in a...

AAN2017. B cells and Disease Activity

348  Relationship between MRI Lesion Count and B Cell Count Reduction under Ofatumumab Treatment  M. Savelieva (Novartis Pharma AG, Basel, Switzerland), J. Kahn (Novartis Pharma AG, Basel, Switzerland), E. Wallstroem (Novartis Pharma AG, Basel, Switzerland), D. Leppert (Novartis Pharma AG, Basel, Switzerland).  Objective: To...

Dimethyl fumarate is it CD8 T cells?

We have made a suggestion that most if not all MS drugs work by targeting a memory B cell subset. So we should attempt to disprove this, which is the science method.  The paper today says Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Therefore is the idea disproved already. When we came up with the B cell idea it was based at...

AAN2017. B cells remain in the brain after rituximab treatment

341 Persistent B lymphocytes in multiple sclerosis plaques after rituximab treatment S. esfandi (University of Colorado), S. Salimian (U of Colorado School of Medicine), J. Corboy (U of Colorado School of Medicine), E. Alvarez (University of Colorado). To describe the persistence of inflammation lymphocytic infiltrates in plaques from a postmortem case of aggressive multiple sclerosis (MS) after...

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