Are we seeing the end of the mousers?


If we do a quick check on the number of papers containing encephalomyelitis for EAE by year and compare it with multiple sclerosis by year, we can see the number of EAE papers have been dropping.

This was running running at about 1100-1200 responses and there were about 5000-6000 responses for multiple sclerosis. This is now

Year                EAE    MS
2017               1076   6056 current x 4
2016                994    5272
2015              1251    5432
2014              1205    5264
2013              1226    5037
2012              1130    4570
2011              1160    4297
2010              1159    4035

There is now less money in the system and maybe the funders are moving on. There are less “severe” to study basic science question for immunology. Have EAE had it’s day?

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    • The idea comes from someone who should not know the history of bioethics, perhaps not know for example Tuskegee cases in the US and the case of the Swedish study on caries in mentally disabled children …

    • Come off it – EAE has helped to skew research into MS. This is apparent to any honest appraisal.

      It is also often pointlessly cruel.

    • It's not about using people instead for experiments Cinara – obviously that is not ethical (either). The point is – how useful is EAE actually – in terms of a therapy for (primary) progressive MS. My opinion, as a PPMSer, is – not very. At least, my neuro is still saying there is nothing on the horizon.

      Maybe EAE is good for RRMS – I don't know, because relapses are alien to me.

    • "Come off it – EAE has helped to skew research into MS. This is apparent to any honest appraisal."
      Well there's a grain of truth in that with some studies, as we have banged on about here on many occasions but any honest appraisal would also reveal that many studies have also been of undoubted value in furthering our understanding of MS and the search for better therapies.
      So, the words baby and bathwater spring immediately to mind.

    • I would suspect that the enormous advancements in RRMS / CIS will impact research in utilization of mice in EAE.

      Ethics is a strange term. Since when is the human race ethical? Perhaps that happened while I was sleeping or in surgery?

      Dang! I missed it! Here I've been waiting since the exodus over 4000 years ago and I MISSED IT!

      Q: Is it ethical to kill cows for steaks, burgers and meatballs? Is it ethical to birth chickens to devour them or their unborn offspring?

      A: Not if your the cow or the chicken.

      Which came first the chicken or the egg?

      Neither, it was the Velociraptor and I do not think the Velociraptor's ever signed off on the "Velociraptor Victims Patient Association" calls for ethics.

      Doesnt matter… In time Exxon, BP and others will usurp all such arrangements.

      EAE has IMHO (and that of the former Velociraptor union est: 65.5M BC) been foundational in moving science ahead in respect to MS and understanding of demyelinating diseases.

      My fear towards MS is what gets construed as a cure within pharma.

      1. If a med stops MS in 94% of RRMS patients does that get considered "good enough" until perhaps something such as regenerative medicine finds the golden fleece.

      2. Towards progressive MS does #1 result in research slowing because of the demographic population?

      MS has made more gains over the past 15 years than any other chronic illness I am aware of. Given the smaller demographics of MS .vs. Lupus, Alz, Parkinson's, Huntingtons its pretty amazing.

      Has EAE played a significant role in that. Oh my gosh yes.

      Is it pointlessly cruel to engage in science in said fashion?

      Pointless cruelty sits within the foundation of many a human being and it resides there without any honorable goals.

      We have an entire world of people who cannot abide by a few handful's of basic principles whether penned by man or some extraterrestrial millenia back. Yet, virtually every one of those billions of people would agree, "The world would be a better place if we did."

      Placing the term ethics in the same sentence as humanity is akin to saying, "Look. There is white stuff falling from the sky. Is it snow or cocaine?"

      Science is the exploration of the universe it is no more gentle nor harsh than the violence that is said universe.

      Has EAE skewed research? Perhaps yes, perhaps no, perhaps someplace in the middle. Its not like a roadmap falls from the heavens saying, "No. EAE is not a model to utilize, genetics are, environment is."

      Science probes many areas and its often not gentle.

      If tomorrow a new truth came forwards, "Electricity is what causes cancer and autoimmune diseases" fact. Do you honestly think humanity would stop? Nope. Instead it would probe ways to mitigate the damage.

      "Eat three sketcher sneaker soles a week, do 22 jumping jacks, take this pill and wear your repulser clothing at all times"

      The result, people take the pill and wear clothing.

      When people consider others more important than themselves and actively and actionably do that as "normal life" then perhaps we can move unto ethics of mice, of mice and men so to speak.

    • "When people consider others more important than themselves and actively and actionably do that as "normal life" then perhaps we can move unto ethics of mice, of mice and men so to speak."

      I am not to question the usefulness of EAE in research into progressive MS and hence the ethics of it until I prove to someone I regard others as more important than myself? I'm vegan, if that helps my case?

      Whilst I am coninced by Dawkins' selfish gene, I think we are all, to a greater or lesser degree motivated by love and ethical considerations. That is the essence of humanity.

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