Cortical lesions (CLs…Lesions on the outer part of the brain) are an important component of multiple sclerosis (MS) pathology; they correlate better with physical disability and cognitive impairment than white matter lesions (WMLs). Because remyelination can be extensive in CLs, we quantified remyelination in gray matter (GM) and white matter (WM), addressing oligodendrocyte (OGD) maturation state and clinical relevance of remyelination.
The reason for demyelination is suggested to be a failure to remyelinate. This has been suggested to be due to loss of oligodendrocyte precursors. So this study says that there is remyelination in the grey matter and these is no real failure to remyelinate grey matter as there are still plenty of precursors cells about. Yet there are grey matter lesions.
However it is known that they remyelinate better, and this was said many years ago.
Chang A, Staugaitis SM, Dutta R, Batt CE, Easley KE, Chomyk AM, Yong VW, Fox RJ, Kidd GJ, Trapp BD. Cortical remyelination: a new target for repair therapies in multiple sclerosis.Ann Neurol. 2012 Dec;72(6):918-26
Hopefully this will protect the cortical nerves from damage, maintaining cognition.
Extensive cortical remyelination in patients with chronic multiple sclerosis.Albert M, Antel J, Brück W, Stadelmann C.
Brain Pathol. 2007 Apr;17(2):129-38.