ArchiveMay 2017

World MS Day

Since 2009 the last Wednesday in May marks World MS Day, raising awareness and facilitating support among MS organisations around the Globe. The Day is coordinated by the Multiple Sclerosis International Federation (MSIF). This year’s theme is #Life with MS. A number of events across the Globe mark the day.  I will be in Belém near Lisbon at an event organised by the British...

World MS Day

Today is World MS day A message from BartsMS P.S. It’s really only 4 minutes long….Have a look You can view ProfG and DrK through his Rose-tinted Glasses. To get any new initiative off the ground you often need pilot data and this takes resource. We have launched BartsMS Charity as vehicle that may allow that to happen in a more timely manner.  It may allow us to tackle...

T regs

Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N. CCR8+FOXp3+ Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017. pii: 201621280. The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg up-regulate CCR8...

World MS Day tomorrow. Introducing #BartsMS-Charity TODAY

I trust most of you are aware tomorrow is: including this event: On this occasion we decided to announce a project we’ve been pondering over for some time.  It is: Don’t worry the logo will look much nicer once our design department are ready:-) What is the objective of BartsMS Charity? To enable Barts-MS to undertake hard-to-fund, or to prime important, MS research...

Life’s a beach

Eur J Neurol. 2017 Jun;24(6):851-857. doi: 10.1111/ene.13301. No relevant impact of ambient temperature on disability measurements in a large cohort of patients with multiple sclerosis. Stellmann JP, Young KL, Vettorazzi E, Pöttgen J, Heesen C. Abstract BACKGROUND AND PURPOSE: Many patients with multiple sclerosis (MS) report a worsening of symptoms due to high ambient temperatures, but objective...

CD44 is it all about the Gut?

There is a real move to suggest that the influence of the immune system is because of bacteria in the gut. Every science meeting has a session on it. The following is one example, but as I get airbrushed out of history I am not so sure it is all so simple Chitrala KN, Guan H, Singh NP, Busbee B, Gandy A, Mehrpouya-Bahrami P, Ganewatta MS, Tang C, Chatterjee S, Nagarkatti P, Nagarkatti M.CD44...

MS isn’t caused by antibodies to myelin

Prineas JW, Parratt JDE. Multiple sclerosis: Serum anti-CNS autoantibodies. Mult Scler. 2017:1352458517706037. BACKGROUND: It is uncertain whether there are autoantibodies detectable by indirect immunofluorescence in the serum of patients with multiple sclerosis (MS).OBJECTIVE: To determine whether there are anti-central nervous system (CNS) autoantibodies detectable by indirect...

Damaging Cholesterol

I recently asked how can statins work in secondary progressive MS. In the absense of any real insight, I came up with a few ideas one of which was involving the cholesterol pathway to control/induce nerve damage Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, Raas Q, de Sèze J, Moreau T, El-Ayeb M, Lizard G. Evidence of K+ homeostasis disruption in cellular...

GABA and Remyelination-Its Confusing I know but no cause for concern

Yesterday I caused a bit of concern by a post on myelination as a GABA (inhibitory nerve transmitter) blocker stimulated developmental myelination, so people were worried about their GABA receptor stimulating drugs. Would they block repair? Answer is I do not definitively know but suspect not. In contrast there could be implications that stimulation of GABA could save nerves. Again we don’t...

First case of PML on Ocrelizumab reported

We have been saying one of the important considerations when starting treatment is how do you switch off your drug, we reported rebound after fingolimod and this is a well known problem with Natalizumab. PML is the other major problem with natalizumab. The first case of PML on ocrelizumab has been reported. Again one suspects that subclinical PML due to natalizumab was the problem. According to...

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