ArchiveJuly 2017

Sorry I messed up

I have to apologise but I was immersed in the World Para Athletics 2017 and the Last Leg and was supposed to launch your comments but deleted them by pressing the wrong button by mistake, so if you have the comments please submit again.

Autoimmunity in MS: Neurofilament light

Puentes F, van der Star BJ, Boomkamp SD, Kipp M, Boon L, Bosca I, Raffel J, Gnanapavan S, van der Valk P, Stephenson J, Barnett SC, Baker D, Amor S. Neurofilament Light as an Immune Target for Pathogenic Antibodies. Immunology. 2017. doi: 10.1111/imm.12797. [Epub ahead of print] Antibodies to neuronal antigens are associated with many neurological diseases including paraneoplastic...

BrainHealth

Today in the News you may hear about brain health to help protect against Dementia from Alzheimer’s. However, these are all relevant to MS too There are 9 things mentioned that may help  The nine risk factors include: Less childhood education Hearing loss Hypertension Obesity Smoking Diabetes Depression Physical inactivity Social isolation Potential risk factors: Pollution Visual loss...

psychiatric disorders in children

Psychiatric disorders in children with demyelinating diseases of the central nervous system.Pakpoor J, Goldacre R, Schmierer K, Giovannoni G, Waubant E, Goldacre MJ. Mult Scler. 2017 Jul 1:1352458517719150. doi: 10.1177/1352458517719150. [Epub ahead of print] INTRODUCTION: The profile of psychiatric disorders associated with multiple sclerosis (MS) may differ in children. We aimed to...

Neutrophil loss after alemtuzumab

Gaitán MI, Ysrraelit MC, Correale J. Neutropenia in Patients With Multiple Sclerosis Treated With Alemtuzumab. JAMA Neurol. 2017 Jul 17. doi: 10.1001/jamaneurol.2017.1456 We all know that alemtuzumab depletes lymphocytes and if you don’t, you should have read our recent papers.  Both cladribine and alemtuzumab may effect MS via B-cell depletion.Baker D, Herrod SS, Alvarez...

Is contrast use in MRI safe?

Radiology. 2014 Mar;270(3):834-41. doi: 10.1148/radiol.13131669. Epub 2013 Dec 7. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D.AbstractPURPOSE: To explore any correlation between the number of previous...

Sunday Challenge.. Literature Review. Does rituximab cause Breast Cancer?

If ocrelizumab, which depletes CD20 B cells, really causes breast cancer (there were non in the the placebo groups in the trials), then based on biology any long-term depletion of CD20 B cells should cause breast cancer if this is true.  Was the ocrelizumab a fluke result as we suggests the the result in the cladribine trial was, after looking at the data from other trials with cladribine...

Breast Feeding is Better

Breastfeeding, ovulatory years, and risk of multiple sclerosis.Langer-Gould A, Smith JB, Hellwig K, Gonzales E, Haraszti S, Koebnick C, Xiang A. Neurology. 2017 Jul 12. pii: 10.1212/WNL.0000000000004207. doi: 10.1212/WNL.0000000000004207. [Epub ahead of print] OBJECTIVE:To determine whether women who breastfeed their infants longer or have fewer ovulatory years are at lower risk of developing...

Cost effectiveness of Ocrelizumab

Yang H, Duchesneau E, Foster R, Guerin A, Ma E, Thomas NP. Cost-effectiveness analysis of ocrelizumab versus subcutaneous interferon beta-1a for the treatment of relapsing multiple sclerosis. J Med Econ. 2017 Jul 13:1-23. doi: 10.1080/13696998.2017.1355310. [Epub ahead of print] AIM: To conduct a cost-effectiveness analysis to compare ocrelizumab versus subcutaneous (SC) interferon beta-1a for...

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