ArchiveAugust 2017

#ClinicSpeak & #GuestPost: how much social capital do you have?

Social capital is important in MS; but how important? #ClinicSpeak #GuestPost Summary: The following post explains the concept of social capital; in essence how socially connected you are. Social capital predicts outcome in many chronic diseases and is closely linked to quality of life (QoL). MS reduces social capital, but by how much? Not enough research has been done on social capital in in the...

A new type of publication will it make a difference?

Alongside growing discontent, the scientific community has answered by driving forward a raft of open science reforms. From initiatives to making research data publicly available, to ensuring that all published research can be read by the public, the aim of these reforms is simple: to make science more credible and accessible, for the benefit of other scientists and the public who...

#ClinicSpeak & #ResearchSpeak: what dose of vitamin D?

What dose of vitamin D supplementation do I recommend? #ResearchSpeak #ClinicSpeak Summary: This blog post makes the case for using an initial dose of vD supplementation (5,000U/day) and then to test blood levels of vD after approximately 6 weeks to adjust the dose accordingly. I use evolutionary medicine to define a treatment target of blood vD levels. The study below has shown that...

Antidote to synthetic Cannabinoids…What has this research got to do with MS?

THIS STORY HAS NOTHING TO DO WITH NALOXONE IN CONTRAST TO THAT INFERRED  BY SOME TWEETS Pryce G, Baker D. Antidote to cannabinoid intoxication: Inverse cannabinoid receptor one (CB1) agonism by N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidse (AM251) reverses the hypothermic effects of cannabinoid receptor one agonism by 1-Naphthalenyl [4...

Guest post: The effects of parental MS on children

By Julie Moberg, MA, RN, PhD, postdoc. at the Danish Multiple Sclerosis Registry and the Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark. Background How multiple sclerosis (MS) among parents affects their children in childhood has been reported in some studies, but little is known about the consequences later in adult life. The...

Minocycline as a neuroprotectant

Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis Luanne M. Metz, M.D., David K.B. Li, M.D., Anthony L. Traboulsee, M.D., Pierre Duquette, M.D., Misha Eliasziw, Ph.D., Graziela Cerchiaro, Ph.D., Jamie Greenfield, M.P.H., Andrew Riddehough, B.Sc., Michael Yeung, M.D., Marcelo Kremenchutzky, M.D., Galina Vorobeychik, M.D., Mark S. Freedman, M.D., Virender Bhan, M.D...

#NewsSpeak: Results from CHANGE-MS Phase 2b Study

Are HERVs in the final common pathway that leads to demyelination in MS? #NewsSpeak #ResearchSpeak It is very difficult for me to comment on these results without seeing the data firsthand. However, as there is no difference at 6-months between active- and placebo-treated subjects this trial must be interpreted as being negative. Please note that GNbAC1 targets the envelope protein of probably...

#ClinicSpeak & #DietSpeak: could diet be the next DMT?

Are you what you eat? How healthy is your diet? #ClinicSpeak #DietSpeak Whilst on holiday I spent several days with a very good friend of mine, from South Africa, who now lives in the US. His wife is a card-carrying dietician, who runs her own consulting business that helps athletes, companies and individuals improve their health and wellness through diet and exercise. After listening to her and...

Whartons Jelly Stem cells do the trick

Hosseini A, Estiri H, Akhavan Niaki H, Alizadeh A, Abdolhossein Zadeh B, Ghaderian SMH, Farjadfar A, Fallah A.Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton’s Jelly Stem Cells Used in EAE Mice Model. Cell J. 2017; 19(3):361-374. OBJECTIVES:Immunotherapy and gene therapy play important roles in...

#NewsSpeak & #ThinkSpeak: blog rejuvenation

We need your help to rejuvenate the blog #NewsSpeak #ThinkSpeak #MSBlog Just back from my family holiday and for the first time in a long time I feel well, have a manageable workload and have a list of things to do in the new academic year that will refocus our research and educational agenda on the things we do best. Whilst away I had a complete break from academic activities including the blog...

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