ArchiveAugust 2017

A new type of publication will it make a difference?

Alongside growing discontent, the scientific community has answered by driving forward a raft of open science reforms. From initiatives to making research data publicly available, to ensuring that all published research can be read by the public, the aim of these reforms is simple: to make science more credible and accessible, for the benefit of other scientists and the public who...

Antidote to synthetic Cannabinoids…What has this research got to do with MS?

THIS STORY HAS NOTHING TO DO WITH NALOXONE IN CONTRAST TO THAT INFERRED  BY SOME TWEETS Pryce G, Baker D. Antidote to cannabinoid intoxication: Inverse cannabinoid receptor one (CB1) agonism by N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidse (AM251) reverses the hypothermic effects of cannabinoid receptor one agonism by 1-Naphthalenyl [4...

Guest post: The effects of parental MS on children

By Julie Moberg, MA, RN, PhD, postdoc. at the Danish Multiple Sclerosis Registry and the Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark. Background How multiple sclerosis (MS) among parents affects their children in childhood has been reported in some studies, but little is known about the consequences later in adult life. The...

Minocycline as a neuroprotectant

Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis Luanne M. Metz, M.D., David K.B. Li, M.D., Anthony L. Traboulsee, M.D., Pierre Duquette, M.D., Misha Eliasziw, Ph.D., Graziela Cerchiaro, Ph.D., Jamie Greenfield, M.P.H., Andrew Riddehough, B.Sc., Michael Yeung, M.D., Marcelo Kremenchutzky, M.D., Galina Vorobeychik, M.D., Mark S. Freedman, M.D., Virender Bhan, M.D...

Whartons Jelly Stem cells do the trick

Hosseini A, Estiri H, Akhavan Niaki H, Alizadeh A, Abdolhossein Zadeh B, Ghaderian SMH, Farjadfar A, Fallah A.Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton’s Jelly Stem Cells Used in EAE Mice Model. Cell J. 2017; 19(3):361-374. OBJECTIVES:Immunotherapy and gene therapy play important roles in...

TeamG helps develop a licenced drug

The new eagle has landed,  As you may know us academics are beaten with a stick to produce papers and to produce papers that have “Impact”. This is some science babble invented to assess research groups by the UK Government As a basic scientist it is very difficult to do something and see it all the way through to have “Impact” on Society, which is what they assess us...

Another eagle? No – a Maven has landed !

It’s official now, oral cladribine (Mavenclad) has just been given the nod by the EU Commission. Whatever the somewhat clumsy detail of the license, and wherever the ensueing discussions with funders will lead on the ground, this is excellent news. Big congratulations to Merck KgA for resurrecting their cladribine programme after BartsMS had started their own given the excellent data...

Vitamin D supplementation during the Winter may be beneficial

Miclea A, Miclea M, Pistor M, Hoepner A, Chan A, Hoepner R. Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity. Brain Behav. 2017 Jul 11;7(8):e00761. OBJECTIVES:Low ultraviolet-B (UVB) radiation causes hypovitaminosis D, which is a known risk factor for multiple sclerosis (MS) and associated with MS disease activity. Our objective is to test whether...

Glatiramer acetate affected gene linked to heart disease gene: A shaggy dog story

Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T; CARDIoGRAM Consortium; CARDIoGRAMplusC4D Consortium, Willer CJ, Laakso M, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J, Schunkert H. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLoS One. 2017 Aug 22;12(8):e0182999...

Effect of DMF is colourblind

Efficacy and Tolerability of Delayed-release Dimethyl Fumarate in Black, Hispanic, and Asian Patients with Relapsing-Remitting Multiple Sclerosis: Post Hoc Integrated Analysis of DEFINE and CONFIRM.Fox RJ, Gold R, Phillips JT, Okwuokenye M, Zhang A, Marantz JL.Neurol Ther. 2017 . doi: 10.1007/s40120-017-0077-5. [Epub ahead of print] INTRODUCTION:Clinical course and treatment response may vary...

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