ArchiveSeptember 2017

Education: B cells are not a single subpoulation

Lehmann-Horn K, Kinzel S, Weber MS. Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function.Int J Mol Sci. 2017 Sep 23;18(10). pii: E2048. doi: 10.3390/ijms18102048. B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple sclerosis (MS). This notion is supported by various immunological changes observed in MS...

Neutrophils lost after alemtuzumab

Marked neutropenia: significant but rare in people with multiple sclerosis after alemtuzumab treatment. David Baker, Gavin Giovannoni, Klaus Schmierer Mult Scler Rel Disord. 2017 . HIGHLIGHTS Neutropenia occurred in 20-25% of people in the 2 year phase III, pivotal trials of alemtuzumab. However, grade 3-4 neutropenia (neutrophils occurred in only 5/811 people with MS (0.6%) in the year following...

Should RIS (radiologically isolated syndrome) be treated?

Mult Scler. 2017 Sep 1:1352458517729462. doi: 10.1177/1352458517729462. [Epub ahead of print] Radiologically isolated syndrome should be treated with disease-modifying therapy-Yes. Okuda DT Radiologically isolated syndrome should be treated with disease-modifying therapy – No Andrés Labiano-Fontcuberta, Julián Benito-León First Published September 14, 2017 MS treatments are a caveat emptor...

Delayed Repopulation white cell population after stopping DMF

Bhupendra O. Khatri, Sergey S. Tarima, Benjamin Essig, Jean Sesing, Tayo Olapo. Delayed lymphocyte re-population following discontinuation of dimethyl fumarate and after switching to other disease modifying drug therapies MSARDS DOI: Background:Dimethyl fumarate (DMF) reduces absolute lymphocyte counts, CD4, and CD8 counts, without significantly affecting total white blood cell counts...

Up in Smoke

Palacios N, Munger KL, Fitzgerald KC, Hart JE, Chitnis T, Ascherio A, Laden F. Exposure to particulate matter air pollution and risk of multiple sclerosis in two large cohorts of US nurses. Environ Int. 2017 Sep 19;109:64-72. BACKGROUND:Air pollution is thought to raise the risk of neurological disease by promoting neuroinflammation, oxidative stress, glial activation and cerebrovascular damage...

How does Daclizumab work? Can animal studies tell us

Bhopale MK, Hilliard B, Constantinescu CS, Phillips SM, Rostami A. DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice. Immunopharmacol Immunotoxicol. 2017 :1-12 CONTEXT: We have reported previously that DAB389IL-2 recombinant fusion toxin targets IL-2R bearing CD4+ cells...

The case for NEDA

I have been asked to look at the paper below, perhaps with a subtext to say how rubbish MS drugs are and how great HSCT is. Rotstein DL, Healy BC, Malik MT, Chitnis T, Weiner HL. Evaluation of no evidence of disease activity in a 7-year longitudinal multiple sclerosis cohort. JAMA Neurol. 2015 Feb;72(2):152-8 IMPORTANCE: With multiple and increasingly effective therapies for relapsing forms of...

Myelin autoimmunity..the delusion complex

Longitudinal analysis of myelin oligodendrocyte glycoprotein antibodies in CNS inflammatory diseases Jae-Won Hyun et al. JNNP 2017  Background We evaluated the seroprevalence of myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG) and associated clinical features of patients from a large adult-dominant unselected cohort with mainly relapsing central nervous system (CNS)...

HSCT in the News

Yesterday in the mail we had another news story on HSCT,  This is Haematopoetic Stem Cell Therapy, which I’m sure you have all heard of as some of our commenters ensure the topic of conversation steers that way every day ……Yawn. You don’t need a neuro to do it and if you have the cash…off you go. Whilst this modus operandi is consistent with most fad...

Social cognition in MS

Eur J Neurol. 2017 Sep 12. doi: 10.1111/ene.13457. [Epub ahead of print] Characterization of social cognition impairment in multiple sclerosis. Neuhaus M, Bagutti S, Yaldizli Ö, Zwahlen D, Schaub S, Frey B, Fischer-Barnicol B, Burgunder JM, Martory MD, Pöttgen J, Annoni JM, Penner IK. Abstract BACKGROUND: Multiple sclerosis (MS) has been associated with deficits in social cognition. However...

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