- Neutropenia occurred in 20-25% of people in the 2 year phase III, pivotal trials of alemtuzumab.
- However, grade 3-4 neutropenia (neutrophils occurred in only 5/811 people with MS (0.6%) in the year following the first infusion cycle and in 12/808 people (1.5%) in the year following the second infusion cycle.
- Agranulocytosis was a rare occurrence but this responded to treatment.
Background: Alemtuzumab is a CD52-specific monoclonal antibody that markedly depletes T and B lymphocytes and inhibits relapsing multiple sclerosis (MS). However, polymorphonuclear neutrophils also express CD52 and can be depleted by alemtuzumab, thereby potentially contributing to the infections that develop post-alemtuzumab treatment. Surprisingly, however, the degree of neutrophil depletion in MS was not included in the pivotal trial reports.Methods: The regulatory submission of the Comparison of Alemtuzumab and Rebif® Efficacy in MS 1 and 2 trials was obtained from the European Medicines Agency through Freedom of Information. The data relating to neutrophils was extracted.
Results: Data extraction from the submission was straightforward. In year one 72/811 (8.9%) and in year two 116/808 (14.4%) people with MS (pwMS) developed neutropenia. The degree of neutropenia was generally mild, and only 5/811 (0.6%) in year 1 and 12/808 (1.5%) in year 2 developed grade 3-4 toxicity. Two pwMS developed severe neutropenia-related adverse events.
Conclusions: Treatment with alemtuzumab induces neutropenia, which is mild in the large majority of pwMS treated. Leucocyte levels following alemtuzumab should be monitored as a marker of efficacy and safety; persistent neutropenia may require treatment
Following on from a recent case report indicating that alemtuzumab, marketed by Sanofi Genzyme, can induce neutropenia (loss of neutrophils, which are your first line of defense against fighting infection), this paper was written and submitted within a few hours.
It is all well an dandy to know that something can occur, but surely it is important to know how common the problem is.
We had it because we had the data set obtained from the European Medicines agency and so we could easily answer the question. Pharma could never write and submit a paper within a few hours.
Will they be miffed, as we have published the information?
Maybe/Probably but the manufacturer has had 7 years to get the data published, as have their academic collaborators, so I should not feel too bad?
I am sure the manufacturers are happy that we have put the case report in context.
But, it says to pharma, that the the world order has changed and now the machinery is at hand to get access to trial data. We have led the way.
So they now pharma can get up to 12-18 months to publish what they want, to publish in a way they want to publish the story, but after that it will be fair game.
Anyway back to the alemtuzumab data set.
It houses quite a lot of unpublished ideas and I had hoped that by publishing some details, such as the presence of neutralizing antibodies, it may have encouraged the academics & company to come clean. It didn’t, so I tell you here again.
Will it be part of the CARE-MS extension data reporting?
It is important as the question is….How many people got anaphylactoid (allergic) responses during infusion?
In the first two years it was very low and you take preventative medicine to prevent this
Importantly how often does the antibody stop working?
These are theoretical problems based on immunological principals
and are a problem for all therapeutic proteins, but is alemtuzumab
One wonders whether the dosing schedule was developed because an issue of neutralizing antibodies was recognised (only 2 course as standard and only retreat at the year end and not when disease activity occurs, as you need to wait for the neutralizing antibodies to subside).
If you are paying $60,000-$80,000 for treatment, you would expect it to work, wouldn’t you?
But I know it doesn’t always, however what is the scale of the issue?
I don’t know, but I can assure you we will get an answer by hook or by crook, with or without company assistance.
Maybe it is not an issue, but let’s see the data!
As MD2 will testify, once the ferret’s jaw locks…it locks..and with no costs and no resource to data crunch we can bide our time.
This is important because omissions by pharma are in the news at present so let’s hope this is not a repeat case.
A report in the Telegraph says
“Medical experts were “complicit” in allowing thousands of children to suffer deformity after resisting warnings on epilepsy drugs, campaigners have said.
“A hearing in London heard that regulators knew in 1973 that taking the anti-epilepsy drug in pregnancy could cause babies to be born with disabilities, but waited 40 years before alerting the public to the risks”. (The regulators have the data to see that there could be an issue of neutralization with alemtuzumab..if they had any immunological knowledge)
In the telegraph article Medical Experts seem to have been suppressing the information flow.