- Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into haematopoietic and connective tissue, whereas MSCs do not differentiate into haematopoietic cells.
It was dubbed a “Search for a Miracle Cure” and was on Channel 4, but there was no evidence presented to suggest it was a cure.
These have been used in motor neuron disease and it is clear it is not a cure.
In the programme, which followed the journey of someone with MS travelling to Israel. One could see ring enhancing gadolinium lesions on the brain scan shown, indicating that disease was active.
However, if you enter being active, due to natural healing you could get better and this is called “regression to the mean“.
I had telecom midway through so will have to watch on catch-up.
However the person in the film had reported return of function in their arm within a couple of hours. So is it remyelination or immunosuppressive I doubt it, as the effect is so quick.
However some anti-inflammatories (NSAIDS) obvious do work within this time frame. But maybe there is a growth factor produced the stem cells.
So it is a placebo effect or maybe there is a symptomatic benefit
However, would it have some effect stopping future disease?
Without the total data it will not be possible to say.
Therefore, a sensational title, that would leave me more deflated by the reality.
However, as it is supposedly blinded we have no idea what the person/people in the film was/were taking.
I asked the PI of the study whether they wanted to do a “Guest Post” to give the grounded view of the study..but no response so far.