out how it can be detected using a simple blood test – up to now the only way
to diagnose the disease has been through an invasive and often painful process
of collecting fluid from the brain and spine”.
and giving you visions of needles in the head.
typical diagnostic test these days and it is certainly not diagnostic as many
conditions have oligoclonal bands. Importantly let’s not forget the good old
magnetic resonance imaging machine for spotting those lesions. This is far more
The project aim was to identify differences in the metabolomic profiles in the serum of patients with multiple sclerosis (MS), those with neuropathic pain (NP) and those with both MS and NP compared with controls and to identify potential biomarkers of each disease state. Metabolomic profiling was performed using ultra-high-performance liquid chromatography coupled to mass spectrometry and the data analysis involved parametric methods, principal component analysis, and discriminating filter analysis to determine the differences between disease and control serum samples. Sphingosine and dihydrosphingosine were identified as significant biomarkers.
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significantly lower in the multiple sclerosis groups compared
with the control group giving p = 6.06 x 10*10. The control
group had a mean peak area of 18, 990
9, 535 ± 3,032 (6,503-12,567)for multiple sclerosis and 11 254 ± 3,863 (8,791-16, 117) for multiple sclerosis
with neuropathic pain.
lower in the multiple sclerosis groups compared with the
control group with p = 4.89 x 10*6
. The control group had
a mean peak area of 7,723 ± 2,345,
whereas the multiple sclerosis groups had mean peak areas of
4,936 ± 1, 389 for MS and 5,904 ± 1,581, respectively. Further studies will also need to be done with other controls.