Alme MN, Nystad AE, Bø L, Myhr KM, Vedeler CA, Wergeland S, Torkildsen Ø. J Neuroimmunol. 2015 Aug 15;285:180-6.
The midline of the corpus callosum was severely demyelinated after acute and chronic cuprizone-induced demyelination. Robust endogenous remyelination was evident after acute, but impaired after chronic, demyelination. FTY720 treatment modestly accelerated myelin recovery after acute but not chronic cuprizone exposure. Markers of gliosis (astrocyte and microglia activation) were not affected by FTY720 treatment. Remarkably, the accumulation of amyloid precursor protein-positive spheroids in axons was less distinct in FTY720-treated animals, indicating that this compound alleviated ongoing axonal damage
Does it affect synapses?
Some reports says it promotes then so that would not answer the question.
Will the other spingospine-1-phophaste inhibitors, likewise fail to slow worsening of hand function?
However if they do promote remyelination, Is the influence of these agents on MS enough to say that remyelination is really going to make a big impact?