ArchiveJanuary 2018

The B cell tide has turned

Now the geneticists are getting involved with suggesting B cells are important in MS. Was our paper on B cells in MS so ace and compelling?:-) or are they on the anti-CD20 gravy train? CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation.  The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a...

A stressed life

Do you suffer from post-traumatic stress disorder? Did you know MS is a potential cause? J Nerv Ment Dis. 2018 Feb;206(2):149-151. doi: 10.1097/NMD.0000000000000780. Prevalence of Posttraumatic Stress Disorder in Patients With Multiple Sclerosis. Carletto S, Borghi M, Scavelli F, Francone D, Perucchini ML, Cavallo M, Pagnini F, Bertolotto A, Oliva F, Ostacoli L. Abstract Chronic and life...

Disease activation after alemtuzumab. Was it the B cells? or the fingolimod?

Rebound disease activity in people taking alemtuzumab. Whats it the B cell surge or Because they had taken fingolimid Activation of disease during therapy with alemtuzumab in 3 patients with multiple sclerosis. Wehrum T, Beume LA, Stich O, Mader I, Mäurer M, Czaplinski A, Weiller C, Rauer S. Neurology. 2018 Jan 19. pii: 10.1212/WNL.0000000000004950. doi: 10.1212/WNL.0000000000004950. [Epub...

Astrocyte as bad guys. A piece in the jigsaw

Whilst hunting through some papers MD2 came across the following paper. I don’t remember seeing it and don’t remember posting on it, so a year late, I thought I would give it an airing especially since the senior author recently passed away. However we are looking for Jigsaw pieces to help understand progressive MS and this, which looks at astrocyte activity, may be one of them...

Trial in Remyelination is safe in humans

You want to hear about remyelination trials and here is one. The idea that there are naturally occurring antibodies that promote remyelination was suggested by the group of Moses Rodriguez at the Mayo clinic many, many years ago.  They then generated an oligodendrocyte/myelin-specific recombinant human monoclonal IgM, rHIgM22. Apparently the antibody is well-endowed with strong anti...

Is the problem of MS due to EBV in the B cells?

What genes are active in MS?  In this study they looked at lesions and surrounding white matter and found a load of CD8 T cells, a lot of CD20 B cells and a few CD4 T cells and plasma cells (antibody making cells). The B cells contained EBV  In this study they take brain tissue and then cut it into very thin slices (eg. a 100th of a mm) and then you look to see if you can find a lesion...

Education: How does a nerve fire?

We have talked about how does a nerve work a number of times but watching a video is much easier. This video was spotted by one out our readers and I think that it explains how a nerve impulse travels pretty nicely. It is well worth the ten minutes to watch it. In MS the signs and symptoms are often caused by the nerves being too excited or under-inhibited, so that the nerve impulses occur in a...

The interpretation of results can depend on the way you look at things.

Look at this picture. What do you see? Do you see an old woment (you see a nose) or a young women (you see a jaw)? Now Look at this. What do you see? Don’t know what this is?. An educational comment for pwMS and researchers It is interleukin 10. It maybe doesn’t mean much to you, but it may help you understand papers a bit better and questions whether you should accept dogma...

Smoking a potential drug interaction in IFNB

Are you a smoker? This is an important post if you are. Neurology. 2018 Jan 17. pii: 10.1212/WNL.0000000000004949. doi: 10.1212/WNL.0000000000004949. [Epub ahead of print] Smoking affects the interferon beta treatment response in multiple sclerosis. Petersen ER, Oturai AB, Koch-Henriksen N, Magyari M, Sørensen PS, Sellebjerg F, Søndergaard HB. Abstract OBJECTIVE: To investigate whether smoking in...

Imaging grey matter atrophy to find the roots of disability

How do we measure nerve loss? The imagers tell us it is grey matter loss that holds the key. So what’s new here? About ten years ago I was at a meeting where a very distinguished MRI expert was saying that ‘whole brain volume’ was not a good outcome measure to monitor progression and that grey matter volume was a much more responsive outcome measure. However, we (the neuros...

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