ArchiveJanuary 2018

The B cell tide has turned

Now the geneticists are getting involved with suggesting B cells are important in MS. Was our paper on B cells in MS so ace and compelling?:-) or are they on the anti-CD20 gravy train? CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation.  The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a...

Is there someone you want to hear from?

You will have noticed over the last 5 months that we have been trying to get more guest bloggers engaged with our blog. We would love to increase the volume of guest posts to increase the diversity of opinions and topics on all things MS. Variety is the spice of life and a lot of what we have to say is repetition.  We don’t want to bore you! You need to hear from other experts in...

A stressed life

Do you suffer from post-traumatic stress disorder? Did you know MS is a potential cause? J Nerv Ment Dis. 2018 Feb;206(2):149-151. doi: 10.1097/NMD.0000000000000780. Prevalence of Posttraumatic Stress Disorder in Patients With Multiple Sclerosis. Carletto S, Borghi M, Scavelli F, Francone D, Perucchini ML, Cavallo M, Pagnini F, Bertolotto A, Oliva F, Ostacoli L. Abstract Chronic and life...

Disease activation after alemtuzumab. Was it the B cells? or the fingolimod?

Rebound disease activity in people taking alemtuzumab. Whats it the B cell surge or Because they had taken fingolimid Activation of disease during therapy with alemtuzumab in 3 patients with multiple sclerosis. Wehrum T, Beume LA, Stich O, Mader I, Mäurer M, Czaplinski A, Weiller C, Rauer S. Neurology. 2018 Jan 19. pii: 10.1212/WNL.0000000000004950. doi: 10.1212/WNL.0000000000004950. [Epub...

Do you want to learn about MS and live in the Middle and Far East?

It is clear that the incidence and prevalence of MS are increasing globally. We are in the throes of an MS pandemic. The one region that is documenting and seeing this change in MS epidemiology is the Middle East and North Africa.  In response to the unmet need, Barts-MS have been invited by the Alfaisal University and Global Academy for Health Sciences (GAHS) to run an MS teaching...

Astrocyte as bad guys. A piece in the jigsaw

Whilst hunting through some papers MD2 came across the following paper. I don’t remember seeing it and don’t remember posting on it, so a year late, I thought I would give it an airing especially since the senior author recently passed away. However we are looking for Jigsaw pieces to help understand progressive MS and this, which looks at astrocyte activity, may be one of them...

Trial in Remyelination is safe in humans

You want to hear about remyelination trials and here is one. The idea that there are naturally occurring antibodies that promote remyelination was suggested by the group of Moses Rodriguez at the Mayo clinic many, many years ago.  They then generated an oligodendrocyte/myelin-specific recombinant human monoclonal IgM, rHIgM22. Apparently the antibody is well-endowed with strong anti...

Is the problem of MS due to EBV in the B cells?

What genes are active in MS?  In this study they looked at lesions and surrounding white matter and found a load of CD8 T cells, a lot of CD20 B cells and a few CD4 T cells and plasma cells (antibody making cells). The B cells contained EBV  In this study they take brain tissue and then cut it into very thin slices (eg. a 100th of a mm) and then you look to see if you can find a lesion...

Education: How does a nerve fire?

We have talked about how does a nerve work a number of times but watching a video is much easier. This video was spotted by one out our readers and I think that it explains how a nerve impulse travels pretty nicely. It is well worth the ten minutes to watch it. In MS the signs and symptoms are often caused by the nerves being too excited or under-inhibited, so that the nerve impulses occur in a...

Tragic news: have you had your flu jab?

I have just heard the tragic news that one of my patients, who was admitted to intensive care over the weekend with pneumonia as a complication of influenza,  sadly passed away last night. I called the patient’s partner to express my sympathy and was surprised to hear that she had not had this season’s flu jab. This is a problem.  We are in the throes of a major, and more...

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