ArchiveFebruary 2018

Genes with progression show us it is inflammatory Start to Finish.

Ageing is part of the MS process. If you are interested in what genes are turned on read here. But it is very clear that inflammation is part of Advanced (progressive) MS **************************************************************** Luchetti S, Fransen NL, van Eden CG, Ramaglia V, Mason M, Huitinga I. Progressive multiple sclerosis patients show substantial lesion activity that correlates...

What predicts cognitive fatigue in MS?

Do you want to make sense of cognitive fatigue? Then this post is for you.  Arch Clin Neuropsychol. 2018 Feb 17. doi: 10.1093/arclin/acy014. [Epub ahead of print] Predictive Models of Cognitive Fatigue in Multiple Sclerosis. Berard JA, Smith AM, Walker LAS. Objective: Cognitive fatigue (CF) can be defined as decreased performance with sustained cognitive effort. The present study examined...

Cellular Expression of CD49d

Natalizumab blocks binding to CD49d = alpha 4 integrin = very late antigen 4 Here is the expression of Message If you wanted to get rid of virus, you may think CD8 effectors cells and plasma cells may be good candidates to block. They express less CD49d   If MS was a problem of CD8 effector cells you could remove the JC virus without blocking MS. If you can, does this tell us that CD8 T...

Can more be done to derisk natalizumab; the case for EID?

Extended-interval dosing (EID) breathes new life into natalizumab. Does this mean our #BrainAttack trial in CIS and an ASCEND II+ trial in SPMS (including wheelchair users) has a chance of getting done (wink-wink)? I have several patients who despite being JCV+ve insist on staying on natalizumab despite alternative treatment options? In fact, I have some patients who after switching to...

Pregnancy

Pregnancy is an important issue with regard to MS, so we try and post the research even if we have nothing much to say Portaccio E, Annovazzi P, Ghezzi A, Zaffaroni M, Moiola L, Martinelli V, Lanzillo R, Brescia Morra V, Rinaldi F, Gallo P, Tortorella C, Paolicelli D, Pozzilli C, De Giglio L, Cavalla P, Cocco E, Marrosu MG, Patti F, Solaro C, Bellantonio P, Uccelli A, Laroni A, Pastò L, Giannini...

Education PNS and CNS axons

Peripheral nervous system and central nervous system nerve axons Mark Baker tells you more about nerves A nerve that we see in the peripheral nervous system (PNS) or a white-matter ‘tract’ in the central nervous system (CNS) is composed of many axons. The axons are elongated extensions of individual nerve cells, and they are structures specialized for signalling over distance. Let me try to...

HSCT and T cells and MS and memory B cells

What cells are important to target in HSCT? Harris KM, Lu T, Lim N, Turka LA. Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity. Front Immunol. 2018 ;9:100. doi: 10.3389/fimmu.2018.00100. eCollection 2018. Autoimmunity represents a broad category of diseases that involve a variety of organ targets and distinct autoantigens. For patients with autoimmune...

TeamG in the News…used for Crowd funding

ProfG and DrK were in the media yesterday as they launched their #Thinkhand campaign. Yep this is old news on the blogsphere, but the Evening Standard (Local London Newspaper) picked up the story and pulled a fast one Lift drugs ban on MS patients who can no longer walk, say doctors Doctors treating people with multiple sclerosis are calling for the scrapping of rules that prevent them...

Putting the CART before the horse: could CAR-T cells be a last-resort therapy in MS to rival HSCT?

First off, apologies my long winter hibernation from the blog. As you may have gathered (if anyone is paying close attention to my blogging habits) I’m no longer full-time at BartsMS, and have been working in mental health down the road at Mile End. There are loads of interesting things to say about the overlap between MS and mental health, lots of which have been discussed before on the...

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