If you wanted to get rid of virus, you may think CD8 effectors cells and plasma cells may be good candidates to block.
They express less CD49d
If MS was a problem of CD8 effector cells you could remove the JC virus without blocking MS. If you can, does this tell us that CD8 T cells do not cause MS?
If you want to get rid of MS, maybe memory B cells would be good to block and for the “deluded” T cell immunologists, CD4 effector cells. They express more CD49d.
Where would natalizumab wear-off first?
ProfG said it may be the influence of other adhession molecules, so what happens to LFA-1 = CD11a which binds to ICAM-1 (CD54).
There is not much on CD8.
Natalizumab blocks binding to CD49d = alpha 4 integrin = very late antigen 4