ArchiveFebruary 2018

Inflammation and nerve damage occur before you even know you have MS

I didn’t realise that NDG had done this but here are my thoughts… They investigated the prognostic value of chitinase 3 like 1 (CHI3L1), neurofilament light chain, and oligoclonal bands for conversion to clinically isolated syndrome (first demyelinating event) and to multiple sclerosis in 75 patients with radiologically isolated syndrome (People with MS-like lesions detected by MRI) ...

Here comes #ChariotMS. Or does it?

Is the #ChariotMS study worth funding? Is upper limb function worth saving in people with more advanced MS? The objectives of our #ThinkHand awareness event, which we are hosting this Thursday night, is to celebrate hand function in people with MS and to promote #ChariotMS to the wider community. It’s all about you. Do you believe #ChariotMS is worthwhile supporting? Should some of the...

Risk of haemolytic anaemia after alemtuzumab

Alemtuzumab use has been associated with the development of secondary autoimmunities. Antibodies to Red blood cells can be one of these di Ioia M, Farina D, di Tommaso V, Travaglini D, Pietrolongo E, Onofrj M, de Luca G. Simultaneous early-onset severe autoimmune haemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis. Mult Scler. 2018 Jan...

Changing Documents. Will it impact on changing practice?

All senior scientists who work in the University sector in the UK are being monitored for their output to determine whether they are of International standing and whether their work has any Impact. Check this out to explain (CLICK. Performance culture is ruining scientific research), it’s quite a sorry state of affairs. What is Impact? Does the work change clinical practice? or perhaps...

Guest post: Double trouble – epilepsy and MS

Seizures have been long recognised as a potential complication of MS (we’ve covered the topic on the blog before), and many studies have been done on its epidemiology and risk factors.  The prevalence of seizure disorders in MS range from 0.89% to 8.06%, but more generally speaking, it is accepted that epilepsy occurs in about 3% of pwMS (Compared to <1% in the general population). So...

Your questions answered: The impact of hormones, sex and gender on MS

As a follow up from my previous post on ‘Why is MS more common in women?‘ I thought I’d respond to some of your comments and questions… As discussed in the previous post, MS is almost 3 times more common in women compared to men and we came to the conclusion that there is a hormonal link, but this may not be the whole reason for the difference between the sexes. It should...

Drugs doing more than one thing, it’s not always good

Morrow SA, Rosehart H, Sener A, Welk B. Anti-cholinergic medications for bladder dysfunction worsen cognition in persons with multiple sclerosis. J Neurol Sci. 2018 385:39-44. Bladder dysfunction is common in persons with MS (PwMS), often due to muscle overactivity. Anti-cholinergic medications are considered the first line treatment for bladder dysfunction and are known to worsen...

Education: What is a nerve impulse?

What is a nerve impulse? How does a nerve axon generate it and allow signalling using impulses from one place to another? The impulse may be thought of as a message or wave.  A ‘message’, for example on a telegraph, or a ‘wave’ in the sea initiates at one point and ends up elsewhere. The message needs the medium: the wave may have travelled great distances, but it cannot exist without the...

Liver toxicity with Teriflunomide (Aubagio) explained

Are you on Teriflunomide (Aubagio)? Then this post is for you.  Toxicology. 2018 Feb 7. pii: S0300-483X(18)30017-9. doi: 10.1016/j.tox.2018.02.003. [Epub ahead of print] Mitochondrial dysfunction induced by leflunomide and its active metabolite. Xuan J, Ren Z, Qing T, Couch L, Shi L, Tolleson WH, Guo L. Abstract Leflunomide, an anti-inflammatory drug used for the treatment of rheumatoid...

Guest post: Why hasn’t the reality of hidden disabilities caught on yet?

Twice in the past couple of months I’ve been reduced to tears because I’ve seen media stories about people with hidden disabilities being treated appallingly by people in customer-facing positions who should be the ones leading the way when it comes to helping those who might need that extra bit of help. In both the stories, the two women were told they didn’t “look disabled.”  As someone...

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