ArchiveMarch 2018

Neuroafilament as a biomarker for brain damage

Are there alternatives to MRI imaging to detect changes? Neurofilament is an internal nerve protein and if you find it in biological fluids, it suggests that you have nerve damage and the root cause of this may be ongoing active inflammation. So it comes are no surprsie that there is a correlation between MRI lesion activity and neurofilament and the more neurofilamet detected the more likely is...

Guest post: Alasdair Coles on An Instinct for Kindness

Prof G asked me to listen to An Instinct for Kindness and offer some comments. As I was mulling over what I might say, I read the posts about the play on this blog: some appreciative, some angry, some disturbed.  I received a similar range of responses to a lecture I once gave to people with MS on “life and death in multiple sclerosis”. I too feel uncomfortable about death. I did not enjoy...

NEDA after ocrelizumab

No-evidence of disease activity (NEDA) means  No Clinical Relapse No New Lesion activity No progression of EDSS ProfG works some magic with Oreclizumab to make it better than any other chemical DMT. What’s he done? Ocrelizumab has become the first treatment for PPMS but there have been complaints that the trials was loaded with people with active disease and so it would respond to...

Familial MS

Keeping it in the family. Brain Behav. 2017 Dec 19;8(1):e00899. doi: 10.1002/brb3.899. eCollection 2018 Jan. Familial multiple sclerosis and association with other autoimmune diseases. Pytel V, Matías-Guiu JA, Torre-Fuentes L, Montero P, Gómez-Graña Á, García-Ramos R, Moreno-Ramos T, Oreja-Guevara C, Fernández-Arquero M, Gómez-Pinedo U, Matías-Guiu J. Objectives: Autoimmune diseases (AID) follow...

B regulatory cells promote remyelination

First we had T regulatory cells promoting remyelination.  In this report it is the turn of the B regulatory cells to do the same thing Tanabe S, Yamashita T. B-1a lymphocytes promote oligodendrogenesis during brain development.Nat Neurosci. 2018 Mar 5. doi: 10.1038/s41593-018-0106-4. [Epub ahead of print] During brain development, the immune system mediates neurogenesis, gliogenesis and...

Estimating the future Prognosis

If you live in the UK, If you haven’t done this yet, why not sign up to the UK MS register. Dennison L, Brown M, Kirby S, Galea I. Do people with multiple sclerosis want to know their prognosis? A UK nationwide study.PLoS One. 2018;13(2):e0193407.BACKGROUND: Multiple sclerosis (MS) has a varied and uncertain trajectory. The recent development of analytical processing tools that draw on...

Is MOG the important autantigen in MS, like it is in EAE

MS is an autoimmune disease…isn’t it. Where is the proof?   There is plenty of circumstantial evidence and there is clearly autoimmunity in MS, but is it the chief problem “Of course it is” I hear many of my colleagues say. Look at EAE, that is autoimmunity and that’s MS isn’t it. Animal studies were centred around autoimmunity to myelin basic protein...

If we #Thinkhand we would have another treatment for Progressive MS.

Another DMT for progressive MS bites the dust! Yet another poorly designed progressive trial. If only it had been designed better it would have transformed the management of SPMS. Have we learnt from our mistakes? Kapoor R, Ho PR, Campbell N, Chang I, Deykin A, Forrestal F, Lucas N, Yu B, Arnold DL, Freedman MS, Goldman MD, Hartung HP, Havrdová EK, Jeffery D, Miller A, Sellebjerg F, Cadavid...

Fingolimod inducing low white blood cell levels but saving brain

What are the consequences of having a low lymphocyte count when starting fingolimod? Ohtani R, Mori M, Uchida T, Uzawa A, Masuda H, Liu J, Kuwabara S. Risk factors for fingolimod-induced lymphopenia in multiple sclerosis.Mult Scler J Exp Transl Clin. 2018 Feb 20;4(1):2055217318759692.  BACKGROUND:Lymphopenia is a well-known adverse event of fingolimod, a disease-modifying drug for...

Adult brain size is affected more by childhood onset MS

Paediatric-onset MS comes at a price; a smaller brain in adulthood. Mult Scler Relat Disord. 2018 Mar 6;21:103-107. doi: 10.1016/j.msard.2018.03.004. [Epub ahead of print] Adult brain volume in multiple sclerosis: The impact of paediatric onset. Fenu G, Lorefice L, Loi L, Sechi V, Contu F, Coghe G, Frau J, Spinicci G, Barracciu MA, Marrosu MG, Cocco E. Abstract BACKGROUND: Paediatric onset...

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