ArchiveMay 2018

Controlling Microglia

Inhibiting Hot microglia is what we think we want. Loss of a molecule involved in growth factor signalling results in the formation of more microglia and worsening of inflammatory conditions.  Some of you may be interested in this one Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Walle LV, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van...

World MS Day 2018

It’s World MS Day today!  This annual awareness day has been pioneered by the MS International Foundation (MSIF) and takes place each year at the end of May. Check here for events across the Globe. This years’s World MS Day campaign headline is #bringinguscloser, which the organisers translate as follows: “Research is bringing us closer to ending MS. To...

It’s in the smell of it all

Mult Scler Relat Disord. 2018 May 18;23:74-77. doi: 10.1016/j.msard.2018.05.006. [Epub ahead of print] Transient impairment of olfactory threshold in acute multiple sclerosis relapse. Bsteh G, Hegen H, Ladstätter F, Berek K, Amprosi M, Wurth S, Auer M, Di Pauli F, Deisenhammer F, Lutterotti A, Berger T. Abstract BACKGROUND: Impairment of olfactory threshold is a feature of early and active...

MS Trust Symptom Challenge – get involved

The MS Trust are continuing to raise awareness about MS by launching the #MSTrustSymptomChallenge! They want you to demonstrate what it feels like to live with certain MS symptoms. Send them videos explaining MS symptoms so young people can understand them.  Could you explain or demonstrate somehow what optic neuritis feels like, or fatigue perhaps? In this video Toby is trying to explain...

Silent Symposium: combination therapies for treating MS

The following two presentations are from last week’s ABN meeting in Birmingham on the topic of the need for combination therapies. It is clear that based on the current efficacy profile of DMTs if we are going to make a difference to people with MS we are going to need to build a sandwich of treatments targeting different pathogenic, including premature ageing. I gave these presentations as...

Learning from Parkinson’s Disease

Have you heard about Participatory Medicine?  At the ABN last week we have a masterful presentation from Prof. Bas Bloem, a neurologist from the Nijmegen in the Netherlands. He is really pushing the bubble in terms of service development in the Parkinson’s Disease (PD) space. He is a big proponent of so-called ‘Participatory Medicine’. The latter is something we at...

Stem cell trial is Safe

Stem cells are the “buzz word” and trials abound. This one reports that they appear safe. However, the question needs to be posed do they work? Are our expectations too high? Rather than write a piece at the end, I have added to the abstract in Magenta Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded...

Scar Wars: Battle of the Labs

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Survey Results: Treating PPMS

In response to my marmite post on ‘Not managing expectations in someone with PPMS‘ I did a survey on treating PPMS. 

You either love it or hate it; a reminder that you can’t please everyone!

The following are the survey results, which I find rather interesting. Thoughts?

ProfG    

Microglial Control of Astrocytes

There is cross talk between glial cells in the CNS, which will contribute to inflammation and damage. Today we have a science post from animals (If not interested don’t read on) looking at mechanisms of this Microglial control of astrocytes in response to microbial metabolites. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C...

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