ArchiveSeptember 2018

The Scottish MS Register Annual Report – 2018

The Scottish MS Register (SMSR) has been collecting data on everyone with a confirmed diagnosis of MS in Scotland since the year 2010. Unfortunately, Scotland has one of the highest rates of MS in the world. The Scottish MS register was set up to count people newly diagnosed with MS, to help monitor service quality and to plan future services for people with MS. Since it started, the Scottish...

CCSVI2..Don’t Do it.

  Messing about with suspected blocked blood vessels led to the CCSVI movement, that was discredited by science,    So yesterday we had the media suggesting that you should block a different vessel in the brain to get rid of MS.    One of the readers asked whether this is the beginning of CCSVI2    It was claimed that a “Team identifies brain’s lymphatic vessels as new avenue to...

Copaxone, why is is not so effective?

I think Glatiramer acetate (at the population level) is a low efficacy treatment. What supports this? Besides the clinical efficacy we have this Pavelek Z, Vyšata O, Sobíšek L, Klímová B, Andrýs C, Vokurková D, Mazurová R, Štourač P, Vališ M. Lymphocyte populations and their change during five-year glatiramer acetate treatment. Neurol Neurochir Pol. 2018 Aug 18. pii: S0028-3843(18)30179-8. doi:...

Shame on Barts Health NHS Trust

  In our patch of East London if you have MS and live in Newham you get a very poor service; for example, you are 3-4 times more likely to require an emergency or non-elective hospital admission compared to if you live in Tower Hamlets or Hackney (our local London boroughs). Why?  We think the main reason is that there are no community-based MS clinical nurse specialists in Newham. We have...

Real-world experience on first line oral therapies DMF and teriflunomide

Comparable efficacy and safety of dimethyl fumarate and teriflunomide treatment in Relapsing-Remitting Multiple Sclerosis: an Italian real-word multicenter experience E D’Amico, A Zanghì, G Callari, G Borriello, A Gallo, G Graziano, P Valentino, M Buccafusca, S Cottone, G Salemi, P Ragonese, R B Bossio, R Docimo, L M E Grimaldi, C Pozzilli, G Tedeschi, M Zappia, F Patti Ther Adv Neurol Disord...

MSexism take two: The Mystery of the Missing Authors

Recently this blog featured an eye-opening article written by our guest blogger Rachel, about gender inequality in the world of multiple sclerosis, from a patient’s point of view. It’s well worth a read. She also outlines just how few women feature on academic panels. And this investigation has now been taken further, with an analysis of authors on academic papers. This post is a rewriting of an...

Rachel Horne interviews ProfG to ascertain why the Department of Health and NICE have said no to ocrelizumab for treating people with PPMS.  “We don’t care a toss about PPMSers, all we are worried about is rationing high-cost drugs and making sure we keep the system simple”, said a DoH spokesperson. “We cannot change the NHS accounting system to have two prices for...

Benign MS. How common is it?

Benign MS is MS is something that I guess you hope for, if you get an MS diagnosis. Likewise if you are a neurologist, benign MS may mean that you don’t  commit to treatment. But how common is this in the UK? Tallantyre EC, Major PC, Atherton MJ, Davies WA, Joseph F, Tomassini V, Pickersgill TP, Harding KE, Willis MD, Winter M, Robertson NP. How common is truly benign MS in a UK...

Socks make Myelin

  More on experimental myelination Mokhtarzadeh Khanghahi A, Satarian L, Deng W, Baharvand H, Javan M. In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis. PLoS One. 2018;13(9):e0203785 We have known for years that neural stems cells form astrocytes and that these can be pushed to become nerves...

Diagnosis MS.Saving 3 years

  The McDonald criteria are diagnostic criteria for multiple sclerosis (MS).They have undergone revisions in 2005, 2010 and 2017 Has this made a difference? 2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes. Gaetani L, Prosperini L, Mancini A, Eusebi P, Cerri MC, Pozzilli C, Calabresi P, Sarchielli P, Di Filippo M. J...

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