Archive2018

Therapeutic Lag

ProfG mentioned the concept of therapeutic lag about why it takes time for MS drugs to work in Progressive MS. Did you get it? Don’t worry many scientists and neurologists don’t get it, so to make it easier for them we have come up with an analogy You can have a science version go and read our Brain paper Here, The MS lesions condition a neurodegenerative environment that does not...

Real Life Use of CD20 depletion

Warning: this post contains an unpleasant image of a skin condition Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study. Yamout BI, El-Ayoubi NK, Nicolas J, El Kouzi Y, Khoury SJ, Zeineddine MM. J. Immunol Res 2018:9084759   OBJECTIVE: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. METHODS: Clinical...

Blood lipids and disease activity are they related?

The headline is “How Lipid Level Tests Can Help People with Multiple Sclerosis”   We have been striving to understand how statins can work in MS. These are cholesterol-lowering drugs.   Altered lipid metabolism is a feature of chronic inflammatory disorders. Increased plasma lipids and lipoproteins have been associated with multiple sclerosis (MS) disease activity. Our objective was...

Alemtuzumab autoimmune problems, this time it is a brain problem

As I said we will be back with more news of of alemtuzumab. This time the person recieving alemtuzumab, developed a brain disease.  They have not found the causative antibody but the person responded to plasma exchange and was the third autoimmunity that the person had:-(  Highlights This case describes the first reported case of autoimmune encephalitis as a secondary autoimmune...

Glial cells involved in progressive MS

We all know that the glial response may be involved in progressive MS Do you want more evidence Masvekar R et al.  Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity MSARDS (Epub):  multiple sclerosis (MS) reaches the progressive stage, immunomodulatory treatments have limited efficacy. This suggests that processes other than...

Pregnancy in MS

Mult Scler. 2018 Dec 3:1352458518816614. doi: 10.1177/1352458518816614. [Epub ahead of print] Pregnancy and multiple sclerosis in the DMT era: A cohort study in Western Austria. Bsteh G, Algrang L, Hegen H, Auer M, Wurth S, Di Pauli F, Deisenhammer F, Berger T. Abstract BACKGROUND:: Multiple sclerosis (MS) predominantly affects women of child-bearing potential. Pregnancy in MS is still a...

Guest post: New study – Are people living with MS in the UK vitamin D deficient?

Help us spread the word, we have a new study open to people living with MS in the UK! This study is looking at vitamin D levels in the MS population and we know that vitamin D research is one of the top research priorities for people living with MS. This strong interest in vitamin D research has been demonstrated by the overwhelming response we have had to this study – but we still need...

Are Neuros Conspiring to Avoid Treatments for Progressive MS

Of course not they want a treatment option, just as you do, but I feel we have been shooting ourselves in the foot and unfortunately this mistake means a bullet to your brain. The question is can we learn from these mistakes? MS-SMART in hindsight appears not so smart as we have backed three losers. So whilst the neuros pat themselves on the back for a trial well done (yes it was a fantastic...

If you have to switch make sure it is effective

Treatment escalation leads to fewer relapses compared with switching to another moderately effective therapy. Chalmer TA, Kalincik T, Laursen B, Sorensen PS, Magyari M; Members of Danish Multiple Sclerosis Group.J Neurol. 2018. doi: 10.1007/s00415-018-9126-y. BACKGROUND Patients with multiple sclerosis who experience disease breakthrough often switch disease-modifying therapy (DMT)...

Side effects and MS drugs

Another report on the drug that just keeps giving….A shame it is giving us extra autoimmunities to be aware of. Pisa M, Della Valle P, Coluccia A, Martinelli V, Comi G, D’Angelo A, Moiola L. Acquired haemophilia A as a secondary autoimmune disease after alemtuzumab treatment in multiple sclerosis: A case report. Mult Scler Relat Disord. 2018;27:403-405. Alemtuzumab is a...

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