Think Hand but now see it


We have been talking about saving hand function, but can we get an understanding of why hand function.

The imagers have been looking and they


Hand motor impairment has considerable effects on daily-life activities of patients with multiple sclerosis (pwMS). Understanding its anatomo-functional substrates is relevant to provide more specific therapeutic interventions.


To investigate the association between hand motor performance and anatomo-functional magnetic resonance imaging (MRI) abnormalities in pwMS.


A total of 134 healthy controls (HC) and 366 pwMS underwent the Nine-Hole-Peg-Test (9HPT), structural and resting state (RS) functional MRI. Multivariate analyses identified the independent predictors of hand motor performance.


PwMS versus HC showed widespread gray matter atrophy (Loss of neurons) , microstructural white matter abnormalities, and decreased resting state functional connectivity in motor (movement) and cognitive (thinking) networks. Predictors of worse right-9HPT ( R2 = 0.52) were decreased right superior cerebellar peduncle and right lemniscus fractional anisotropy (FA) ( p ⩽ 0.02),

This image has an empty alt attribute; its file name is peduncles-14B7066F221500A24E0.jpg
This image has an empty alt attribute; its file name is FG16_02a.jpg

left angular gyrus atrophy ( p < 0.003),

The angular gyrus is a region of the brain lying mainly in the anterolateral region of parietal lobe, that lies near the superior edge of the temporal lobe, and immediately posterior to the supramarginal gyrus.

Angular gyrus is orange

decreased RS connectivity in left superior frontal gyrus, (green below)

and left posterior cerebellum ( p < 0.001). (Back of the cerebellum)

Worse left 9HPT ( R2 = 0.56) was predicted by decreased right corticospinal FA ( p = 0.003), atrophy of left anterior (front) cingulum and left cerebellum ( p ⩽ 0.02),

decreased RS connectivity of left lingual gyrus and right posterior

cerebellum in cerebellar and executive networks ( p ⩽ 0.02).


Structural and functional abnormalities of regions involved in motor functions contribute to explain motor disability in pwMS. The integration of clinical and advanced MRI measures contributes to improve our understanding of multiple sclerosis clinical manifestations

So there you have it and shows how lots of brain areas are involved in the control of hand function

About the author



  • I can think hand endlessly but with SPMS and no treatment available that is not much use is it? And lovely as the peg test is there is not much point in me using it to tell me if I am getting worse with nothing that can be done !

By MouseDoctor



Recent Posts

Recent Comments