We have been talking about saving hand function, but can we get an understanding of why hand function.
The imagers have been looking and they
Hand motor impairment has considerable effects on daily-life activities of patients with multiple sclerosis (pwMS). Understanding its anatomo-functional substrates is relevant to provide more specific therapeutic interventions.
To investigate the association between hand motor performance and anatomo-functional magnetic resonance imaging (MRI) abnormalities in pwMS.
A total of 134 healthy controls (HC) and 366 pwMS underwent the Nine-Hole-Peg-Test (9HPT), structural and resting state (RS) functional MRI. Multivariate analyses identified the independent predictors of hand motor performance.
PwMS versus HC showed widespread gray matter atrophy (Loss of neurons) , microstructural white matter abnormalities, and decreased resting state functional connectivity in motor (movement) and cognitive (thinking) networks. Predictors of worse right-9HPT ( R2 = 0.52) were decreased right superior cerebellar peduncle and right lemniscus fractional anisotropy (FA) ( p ⩽ 0.02),
left angular gyrus atrophy ( p < 0.003),
The angular gyrus is a region of the brain lying mainly in the anterolateral region of parietal lobe, that lies near the superior edge of the temporal lobe, and immediately posterior to the supramarginal gyrus.
decreased RS connectivity in left superior frontal gyrus, (green below)
and left posterior cerebellum ( p < 0.001). (Back of the cerebellum)
Worse left 9HPT ( R2 = 0.56) was predicted by decreased right corticospinal FA ( p = 0.003), atrophy of left anterior (front) cingulum and left cerebellum ( p ⩽ 0.02),
decreased RS connectivity of left lingual gyrus and right posterior
cerebellum in cerebellar and executive networks ( p ⩽ 0.02).
Structural and functional abnormalities of regions involved in motor functions contribute to explain motor disability in pwMS. The integration of clinical and advanced MRI measures contributes to improve our understanding of multiple sclerosis clinical manifestations
So there you have it and shows how lots of brain areas are involved in the control of hand function