ArchiveFebruary 2019

ADIOS Trial. Does it mean Good-Bye?

Did you know that ProfG came up with the name of Pulse Immune Reconstitution Therapy or PIRT to explain how alemtuzumab worked? This refers to the long-term benefit from a short-term treatment cycle of an immune depleting agent But this abbreviation did not last long:-( We still have IRT and Selective IRT (SIRT) and non-selective (NIRT), which of course can be DIRT (Dangerous Immune...

Are you a Barts MS patient and fancy a (free) coffee?

CC_poster Starting this Friday, the 1st of March, two Barts MS patients will be piloting a new patient led initiative – Coffee and a Chat. Bonnie and Elizabeth are volunteering their time to meet and chat with other Barts MS patients in the hope to set up a friendly support network. They’re testing out hosting this in the Nucleus cafe in the Blizard building in Whitechapel (E1 2AT) from...

The Barancik MS Prize

An interview with philanthropists Charles and Margery Barancik. “Through our family foundation we deal with many issues, but our soul is in this one.” On Thursday leading neuroscientist Katerina Akassoglou will take to the stage to speak about her work investigating the blood-brain barrier when she receives the Barancik Prize for Innovation in MS Research at the Americas Committee for Treatment...

Answer to the Grey Matter Question

So last week I set you the task of answering some questions related to the belief that the cause of progressive MS was found. β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J...

MS as an indication for HSCT – an American perspective

Dr Luddites As HSCT’s (Haemopoeitic Stem Cell Transplantation) popularity grows, the need for guidance and regulation grows in equal measure. Which is why in 2015, the American Society for Blood and Bone Marrow Transplantation (ASBMT) designated MS as a ‘developmental’ indication for HSCT, but has since reconsidered its position.It must be remembered that HSCT is a technology...

Can you have it both ways?

As you know there has beeen a suggestion that if you have more salt it drives pathogenic T cells in MS. MD2 suggested that the animal data on which this idea is based (OK there is a corrleation of more MS and more Burger bars….Maybethe link is greenhouse gas-or is that hot air?) was a croc based on the dose equivalents that you would have to eat half a kilo a day. Not deterred scientitsts...

The cause of Progressive MS is here. Its Grey matter Directed T cells… Really?

What is the difference between relapsing and progressive MS. This new work from one of the number one science comics now tells us that it is due to immune cells responding to a grey matter protein called beta synuclein Nature | Published: 20 February 2019 β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration Dmitri Lodygin et al. ,  The grey matter is a central target of...

MS-STAT2 – Simvastatin for Secondary Progressive MS

Thank you to Prof. G, MouseDoctor and the Barts MS team for letting us reach out to you about the MS-STAT2 study! Are you interested in taking part? We would love to have you involved! Follow the link for more details and to register your interest: www.ms-stat2.info MS-STAT2 – What is it? The MS-STAT2 study is a 3 year clinical trial testing whether high dose simvastatin can slow down the rate of...

How does cladribine work?

As promised, I now provide you with a link that will provide you with full and free access to the paper for fifty days. You can download, read and come back to ask questions. Here is the link.

Enjoy.
COI Multiple This was not company sponsored

Spanner in the works for intrathecal rituximab

Figure: To-and-fro bi-directionality of CSF flow in the brainBy © Nevit Dilmen, CC BY-SA 3.0 I get a sinking feeling in the pit of my stomach when I read this article. Starting out in science, one is considered smart when following the trends of the populist. As a seasoned scientist, when one continues to work in this way, one is just not being too clever. I am not being disparaging of those who...

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