ArchiveFebruary 2019

ADIOS Trial. Does it mean Good-Bye?

Did you know that ProfG came up with the name of Pulse Immune Reconstitution Therapy or PIRT to explain how alemtuzumab worked? This refers to the long-term benefit from a short-term treatment cycle of an immune depleting agent But this abbreviation did not last long:-( We still have IRT and Selective IRT (SIRT) and non-selective (NIRT), which of course can be DIRT (Dangerous Immune...

#AttackMS – a flipped pyramid

Why does Selma Blair’s speech sound slurred? Whenever a celebrity gets MS and comes out of the ‘closet’ MS trends on social media. When Selma Blair attended the Oscar ceremony on Sunday night walking with a cane it caused quite a stir. You can now watch an interview with her on ABC News. You will notice that she has a slurred speech, which we call dysarthria and she is unsteady...

Are you a Barts MS patient and fancy a (free) coffee?

CC_poster Starting this Friday, the 1st of March, two Barts MS patients will be piloting a new patient led initiative – Coffee and a Chat. Bonnie and Elizabeth are volunteering their time to meet and chat with other Barts MS patients in the hope to set up a friendly support network. They’re testing out hosting this in the Nucleus cafe in the Blizard building in Whitechapel (E1 2AT) from...

Yin and Yang

What is your worldview of MS? Back in 1982 when I was in 1st-year medical school I had the good fortune of being taught by Professor David Hammond-Tooke, an eccentric social anthropologist, whose task was to make us view the world from different cultural perspectives. I was living in apartheid South Africa and Wits, a liberal English speaking University, wanted its medical graduates prepared for...

The Barancik MS Prize

An interview with philanthropists Charles and Margery Barancik. “Through our family foundation we deal with many issues, but our soul is in this one.” On Thursday leading neuroscientist Katerina Akassoglou will take to the stage to speak about her work investigating the blood-brain barrier when she receives the Barancik Prize for Innovation in MS Research at the Americas Committee for Treatment...

Answer to the Grey Matter Question

So last week I set you the task of answering some questions related to the belief that the cause of progressive MS was found. β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J...

MS as an indication for HSCT – an American perspective

Dr Luddites As HSCT’s (Haemopoeitic Stem Cell Transplantation) popularity grows, the need for guidance and regulation grows in equal measure. Which is why in 2015, the American Society for Blood and Bone Marrow Transplantation (ASBMT) designated MS as a ‘developmental’ indication for HSCT, but has since reconsidered its position.It must be remembered that HSCT is a technology...

A call to arms – the need for a citizens jury on HSCT

A few weeks ago I did a post on using a Citizens Jury, as a potential way to deal with the emotive issue of a lack of access to HSCT as a potential 1st-line treatment for active MS in the UK. A Citizens Jury can help sort out the disconnect between the needs or implied needs, of the MS community, and the position of the NHS and/or the HCPs in relation to HSCT. A Citizens’ jury is when a group of...

Can you have it both ways?

As you know there has beeen a suggestion that if you have more salt it drives pathogenic T cells in MS. MD2 suggested that the animal data on which this idea is based (OK there is a corrleation of more MS and more Burger bars….Maybethe link is greenhouse gas-or is that hot air?) was a croc based on the dose equivalents that you would have to eat half a kilo a day. Not deterred scientitsts...

Flipping the pyramid

Was the concept of flipping the pyramid as a treatment strategy explained to you when you were started on a DMT? For several years I have been arguing for adopting the concept of flipping the pyramid as a treatment strategy for MS. This is a treatment strategy developed by rheumatologists for treating rheumatoid arthritis with great success. In short, flipping the pyramid is using very high...

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