ArchiveMarch 2019

Maven has Landed on the other side of the pond

Thanks FDA….you made our REF2021 impact statement even better!!!!…… Only joking.. but today signals a new chapter in our journey with cladribine. The MDs became CLAD lads way back in December 2004, when we did our first experiment with cladribine. We saw the potential of the intravenous and subcutaneous variant in MS and had spotted that we could develop an oral variant, if we...

Coffee and Chat reminder

Next Friday! Come along to Coffee and Chat. If you are a Barts-MS patient, make sure you head to Whitechapel for a new patient-led group – Coffee and a Chat. Bonnie and Elizabeth have set up this friendly support network for all patients of Barts-MS. Come along to the Nucleus cafe in the Blizard building in Whitechapel (E1 2AT) from 10am – 12pm on the first Friday of each month through 2019. The...

Trying to understand whether a sneaky fag is bad for you?

The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.Enzmann G, Adelfio R, Godel A, Haghayegh Jahromi N, Tietz S, Burgener SS, Deutsch U, Wekerle H, Benarafa C, Engelhardt B. Int J Mol Sci. 2019 Mar 21;20(6). pii: E1433. doi: 10.3390/ijms20061433. Multiple sclerosis (MS) is the most common inflammatory disorder...

Newsflash new addition for secondary progressive MS

Treatment arrives for secondary progressive MS. Siponimod has been approved by the FDA in the US. This can be used from clinically.isolated syndrome onwards. So why would you want fingolimod? I wonder. They work the same way but siponimod may have lesser side effects. What will NICE do? keep it second.line like fingolimod or.give it a first line licence. I guess it depends on what the EMA say...

DMF versus Teriflunomide

Treatment algorithm (Ingwersen J et al.) Did I hear you say injectables, what injectables? The turf war in the first-line RRMS treatments is clearly between the two oral therapies; dimethyl fumarate (DMF) and teriflunomide (Teri)!Each have their Achilles heel. DMF with its lymphopenia (drop in lymphocyte counts) and Teri with its transaminitis. So, it isn’t surprising that the weighing...

If it looks like a duck , quacks like a duck..its a duck. DMT are worthwhile

Changes in the Risk of Reaching Multiple Sclerosis Disability Milestones In Recent Decades: A Nationwide Population-Based Cohort Study in Sweden.Beiki O, Frumento P, Bottai M, Manouchehrinia A, Hillert J. JAMA Neurol. 2019 Mar 18. doi: 10.1001/jamaneurol.2019.0330. [Epub ahead of print IMPORTANCE:Clinicians’ experience and findings from recent natural history studies suggest that...

Calling all male MSers

Do men with MS deserve to be offered higher efficacy DMTs earlier than women? When you do a baseline prognostic profile of someone with MS, being female is a good prognostic factor compared to being a male. Men have a worse outcome. This study below shows men do worse when it comes to poor cognition compared to women (#ThinkCognition). The question of why women do better cognitively may relate to...

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