ArchiveApril 2019

Fatigue in MS – what we don’t know?

Fatigue in MS is a strange duck, on many levels obvious and frequently described by PwMS (80-90%), but one that lacks sound medical explanation and science doesn’t even know how to test it yet. I was sure that the fatigue in MS, particularly exercise induced fatigue, was somehow related to the conduction block caused by the demyelination in the long tracts (corticospinal tract). It would...

More evidence that myelin basic protein is unlikely to be a major target in MS.

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis.Faigle W, Cruciani C, Wolski W, Roschitzki B, Puthenparampil M, Tomas-Ojer P, Sellés-Moreno C, Zeis T, Jelcic I, Schaeren-Wiemers N, Sospedra M, Martin R.Front Immunol. 2019 Apr 10;10:540 “Immune responses to citrullinated (or deimination is the conversion of the...

You thought bassoon was a musical instrument. So did I. Let’s learn together and ask are we doing the right thing

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA. Nat Neurosci. 2019 Apr 22. doi: 10.1038/s41593-019-0385-4. [Epub ahead of...

Guest post: Social capital and social prescribing

I was having a chat with a friend a few days ago. He said “I have heard people talking about social capital and social prescribing. I don’t really know what they mean, do you?” “Umm, not too easy”, I said. “I know it’s nothing to do with money, it’s not measurable and it’s all to do with your quality of life”. “Sounds interesting”! He wanted to know more but I could not really help him right then...

Guest post: Part three of choosing a DMT: Understanding risk

DMTs carry a much higher degree of risk than nothing at all and the reality of MS means that attitudes towards risk need adjusting. It is fine to come into the scenario assessing things in a pre-diagnosis manner, that is understandable. A patient needs educating about the whole post-diagnosis scenario now. The lens through which risk, regarding treatments, has changed. From the risks of opting...

Reminder: your chance to influence preventive research!

Here is a reminder to book your place on next week’s preventive neurology discussion: your chance to influence the direction of research taken by the Preventive Neurology group. Here are the details if you missed the last post: The Preventive Neurology Unit are hosting an afternoon of informal conversations on the 30th April with people who have a particular interest in MS, Parkinson’s...

Re-vitalise your gut

Gut microbiome The lions share of the risk (~70%) for developing MS is attributable to environmental risk, while genetics explains bulk of the remaining risk. The environmental risk factors studied in MS have been manifold, ranging from the latitude effect, to viruses, and may well explain some of the heterogeneity that we observe. For some time now, researchers have been looking at an imbalance...

Oligodendrocytes do everything? They disrupt the blood brain Barrier

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. Nat Neurosci. 2019 Apr 15. doi: 10.1038/s41593-019-0369-4. [Epub ahead of print]. Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple...

A moan…Doing trials to pat yourselves on the back for a paper and a job well-done is not what it’s about… Changing clinical practise is what it’s all about

A couple of years ago Dr Raj Kappoor and ProfG did a trial in optic neuritis and tested a sodium channel blocker to see if it could save nerves in the eye after optic neuritis. This was based on studies that MD1, 2, 3 & 4 had done in the beasties. The trial worked and it saved loss of nerves by about 30%, but then what?….Yep Nothing. I said to the neuros..”You have done a trial...

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