Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. Nat Neurosci. 2019 Apr 15. doi: 10.1038/s41593-019-0369-4. [Epub ahead of print].
Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury. We find perivascular clustering of oligodendrocyte precursor cells (OPCs) in certain active MS lesions, representing an inability to properly detach from vessels following perivascular migration. Perivascular OPCs can themselves disrupt the BBB, interfering with astrocyte endfeet and endothelial tight junction integrity, resulting in altered vascular permeability and an associated CNS inflammation. Aberrant Wnt tone in OPCs mediates their dysfunctional vascular detachment and also leads to OPC secretion of Wif1, which interferes with Wnt ligand function on endothelial tight junction integrity. Evidence for this defective oligodendroglial-vascular interaction in MS suggests that aberrant OPC perivascular migration not only impairs their lesion recruitment but can also act as a disease perpetuator via disruption of the BBB.
As it in Nature you may be interested in this study. They suggest that oligodendrocytes are a problem and cause blood brain barrier dysfunction. They claim that oligodendrocytes clustering around lesions is a problem. Given that people spent a lot of time hunting for OPC in MS, why wasn’t OPC clustering reported before? I will ask a pathologist if they see this, but I suspect I know the answer…but will keep an open mind.
But there is never a new idea is there…but its in Nature neuroscience..surely its new
Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury Ji Hae Seo, Nobukazu Miyamoto, Kazuhide Hayakawa, Loc-Duyen D. Pham, Takakuni Maki, Cenk Ayata, Kyu-Won Kim, Eng H. Lo,and Ken Arai First published January 2, 2013 J clin Invest
The studies are different but surely worth a mention as background information if nothing else. Who reviewed this paper Ken Arai apparently