Oligodendrocytes do everything? They disrupt the blood brain Barrier

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Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ. Nat Neurosci. 2019 Apr 15. doi: 10.1038/s41593-019-0369-4. [Epub ahead of print].

Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury. We find perivascular clustering of oligodendrocyte precursor cells (OPCs) in certain active MS lesions, representing an inability to properly detach from vessels following perivascular migration. Perivascular OPCs can themselves disrupt the BBB, interfering with astrocyte endfeet and endothelial tight junction integrity, resulting in altered vascular permeability and an associated CNS inflammation. Aberrant Wnt tone in OPCs mediates their dysfunctional vascular detachment and also leads to OPC secretion of Wif1, which interferes with Wnt ligand function on endothelial tight junction integrity. Evidence for this defective oligodendroglial-vascular interaction in MS suggests that aberrant OPC perivascular migration not only impairs their lesion recruitment but can also act as a disease perpetuator via disruption of the BBB.

As it in Nature you may be interested in this study. They suggest that oligodendrocytes are a problem and cause blood brain barrier dysfunction. They claim that oligodendrocytes clustering around lesions is a problem. Given that people spent a lot of time hunting for OPC in MS, why wasn’t OPC clustering reported before? I will ask a pathologist if they see this, but I suspect I know the answer…but will keep an open mind.

But there is never a new idea is there…but its in Nature neuroscience..surely its new

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury Ji Hae Seo, Nobukazu Miyamoto, Kazuhide Hayakawa, Loc-Duyen D. Pham, Takakuni Maki, Cenk Ayata, Kyu-Won Kim, Eng H. Lo,and Ken Arai First published January 2, 2013 J clin Invest

The studies are different but surely worth a mention as background information if nothing else. Who reviewed this paper Ken Arai apparently

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MouseDoctor

8 comments

  • Interestingly, if you read the paper beyond just the abstract, you will see that the that other paper you mentioned above is quite a different concept. Also, one of the reviewers of the Nature Neuroscience paper (Ken Arai) who is acknowledged by Nature Neuroscience at the end of the paper is the senior author on that 2013 paper, so I guess they must have figured it was interesting original work.

  • This comment is one of the most ignorant I have read: ‘Given that people spent a lot of time hunting for OPC in MS, why wasn’t OPC clustering reported before? I will ask a pathologist if they see this, but I suspect I know the answer’. The whole point of all science is to try to discover new unreported findings that move our understanding of a disease forward. There is a huge amount not known about the pathology of MS, that is why people still study it, to try and discover and help people with the disease.

    Also this comment is very ignorant: “Ooops…Big question was it cited…Answer is No….Who reviews this stuff……….their mates?” If you noticed or read the paper properly, one of the reviewers is actually the senior author on that 2013 paper you so smartly mention.

    • Chastised…Eeek…but I will keep an open mind and wait to hear what I hear. However, let’s not kid ourselves that every thing in science is clear cut as there are plenty of examples of pathology that others do not see. You put an idea out there, you hope that people embrace it, you really hope that people can reporduce it..Time will tell.

      • OPC first reaction “you see them everywhere and also in clusters” so not that new…however B cells are found in clusters and some people call them follicles when they are not. Will these clusters centre around blood vessels let’s see…I’ll keep an open mind..is that ignorant? Cynical perhaps…but hey the eye has a blood retinal barrier and you get blood retinal breakdown with diseae but hey no myelin in the retina…what’s the cause?

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