Why do we do this?
Well a few years ago the collaborators of Prof Franklin sewed a young and an old mouse together and gave the old mouse a young mouse’s blood supply. This gruesome experiment is called parabiosis and is frowned upon in the UK as unacceptable science…The stress of the procedure must be horrendous. Imagine being sewn to a bully who is going to torment you…or imagine being stitched to a pervert. However, Mary Shelly would have been proud of this as she created a monster.
You don’t repair as well when you are older and this is shown again,
Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.Rivera FJ, de la Fuente AG, Zhao C, Silva ME, Gonzalez GA, Wodnar R, Feichtner M, Lange S, Errea O, Priglinger E, O’Sullivan A, Romanelli P, Jadasz JJ, Brachtl G, Greil R, Tempfer H, Traweger A, Bátiz LF, Küry P, Couillard-Despres S, Franklin RJM, Aigner L. Glia. 2019 Apr 30. doi: 10.1002/glia.23624. [Epub ahead of print]. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that leads to severe neurological deficits. Due to their immunomodulatory and neuroprotective activities and their ability to promote the generation of oligodendrocytes, mesenchymal stem cells (MSCs) are currently being developed for autologous cell therapy in MS. As aging reduces the regenerative capacity of all tissues, it is of relevance to investigate whether MSCs retain their pro-oligodendrogenic activity with increasing age. We demonstrate that MSCs derived from aged rats have a reduced capacity to induce oligodendrocyte differentiation of adult CNS stem/progenitor cells. Aging also abolished the ability of MSCs to enhance the generation of myelin-like sheaths in demyelinated cerebellar slice cultures. Finally, in a rat model for CNS demyelination, aging suppressed the capability of systemically transplanted MSCs to boost oligodendrocyte progenitor cell (OPC) differentiation during remyelination. Thus, aging restricts the ability of MSCs to support the generation of oligodendrocytes and consequently inhibits their capacity to enhance the generation of myelin-like sheaths. These findings may impact on the design of therapies using autologous MSCs in older MS patients.
Well you can all read and suggests doom and gloom for older people and that has been seen to be an issue with anti-LINGO-1 antibody where people who are younger respond to treatment.
Does that spell bad news for older people? Well the good news is that you can get rejuvenated or should I say your phagocytes can as they have to hoover-up the debris before repair can occur. How do you you do it. Well there is more than one way to achieved this and ProfF has their own way of doing it. It has been spoken about but I’ll wait until it is published before I say more.