ArchiveJune 2019

Science created FAD

CCSVI came along as a FAD treatment and we (academics) were kicking ourselves for not getting into the social media space to counter the claims going round the web about the wonder cure. It started off with a bit of science and mushroomed into something different. However, we can’t blame Social Media for the the Microbiome fad. This is something that we have created and people are buying...

Plea

I am at the European Academy of Neurology (EAN) congress in Oslo. It is quite clear that in the message of brain health and the holistic management of MS has moved center stage. Everyone is talking about #BrainHealth.  The emphasis is now on early diagnosis, early effective treatments and maximising brain health as a treatment goal. To do this we need a full toolbox of treatments, new therapies...

Treat early and effectively

You may think I am a stuck record , Yes I am. But I need to keep crapping -on because some people just aren’t listening!. I am so, so saddened that some of my so called colleagues…well ProfG’s colleagues are unable to assimilate knowledge and are quite happy to do nothing….but watch as people in their care deteriorate. How much evidence do we need to say that getting on...

Journal Club…Lab lession, re-inventing the wheel to find lesions

Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye Maryna Baydyuk, David S. Cha, Jingwen Hu, Reiji Yamazaki, Evan M. Miller, Victoria N. Smith, Katherine A. Kelly, and Jeffrey K. Huang PNAS To develop therapeutic strategies that enhance repair processes during central nervous system (CNS) injury, the molecular and cellular changes...

Unassisted

Let’s talk about death, that is unassisted suicide.  The meta-analysis below, not surprisingly, shows that if you have MS your chances of suicide are about twice the background rate. The risk is particularly high at diagnosis compared to symptom onset. I suspect this latter is an artificial finding; if you commit suicide before you are diagnosed with MS the code ‘multiple sclerosis’ is...

Should I be apologising

Alemtuzumab in Multiple Sclerosis: Short- and Long-Term Effects of Immunodepletion on the Peripheral Treg Compartment. Haas J, Würthwein C, Korporal-Kuhnke M, Viehoever A, Jarius S, Ruck T, Pfeuffer S, Meuth SG, Wildemann B. Front Immunol. 2019 Jun 4;10:1204 Treatment with alemtuzumab is followed by an early increase in Treg frequencies. Whether naïve and memory subsets are differentially...

How conscientious are you?

Conscientiousness like other higher function traits is advantageous to the modern society in aggregate, as well as individually. It may even be evolutionarily adaptive: “In several respects, conscientiousness is an unusual personality trait. Because hunter-gatherer life did not require as much planning and memory for debts and duties as life in larger-scale societies with more complex...

Cubed

How do we colour in each block of this cube? Making a decision about which DMT to prescribe, or preferably to help your patients make a decision, many of my colleagues mix up their priorities. For example, some mix-up baseline prognostic profiling and disease activity, and then some of them throw disease-stage or disability progression into the mix. I think this occurs because these factors are...

Two strikes your out….Prozac doesn’t make the cut in Progressive MS…Again

Fluoxetine in progressive multiple sclerosis: The FLUOX-PMS trial. Cambron M, Mostert J, D’Hooghe M, Nagels G, Willekens B, Debruyne J, Algoed L, Verhagen W, Hupperts R, Heersema D, De Keyser J; FLUOX-PMS Study Group. Mult Scler. 2019 Jun 20:1352458519843051.  BACKGROUND: Preclinical studies suggest that fluoxetine has neuroprotective properties that might reduce axonal...

Bandwagon

Our microbiomes are clearly very important, but they don’t come close to explaining why you get MS and whether or not one of our microbiomes is causal in MS. Yes, there are multiple microbiomes in and on our bodies. At the moment the attention is all focused on the gut microbiome, in particular, the distal colon. Why? Because it is easy to collect poo samples. But why the colonic microbiome in MS...

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