ArchiveJune 2019

Science created FAD

CCSVI came along as a FAD treatment and we (academics) were kicking ourselves for not getting into the social media space to counter the claims going round the web about the wonder cure. It started off with a bit of science and mushroomed into something different. However, we can’t blame Social Media for the the Microbiome fad. This is something that we have created and people are buying...

Treat early and effectively

You may think I am a stuck record , Yes I am. But I need to keep crapping -on because some people just aren’t listening!. I am so, so saddened that some of my so called colleagues…well ProfG’s colleagues are unable to assimilate knowledge and are quite happy to do nothing….but watch as people in their care deteriorate. How much evidence do we need to say that getting on...

Journal Club…Lab lession, re-inventing the wheel to find lesions

Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye Maryna Baydyuk, David S. Cha, Jingwen Hu, Reiji Yamazaki, Evan M. Miller, Victoria N. Smith, Katherine A. Kelly, and Jeffrey K. Huang PNAS To develop therapeutic strategies that enhance repair processes during central nervous system (CNS) injury, the molecular and cellular changes...

Should I be apologising

Alemtuzumab in Multiple Sclerosis: Short- and Long-Term Effects of Immunodepletion on the Peripheral Treg Compartment. Haas J, Würthwein C, Korporal-Kuhnke M, Viehoever A, Jarius S, Ruck T, Pfeuffer S, Meuth SG, Wildemann B. Front Immunol. 2019 Jun 4;10:1204 Treatment with alemtuzumab is followed by an early increase in Treg frequencies. Whether naïve and memory subsets are differentially...

How conscientious are you?

Conscientiousness like other higher function traits is advantageous to the modern society in aggregate, as well as individually. It may even be evolutionarily adaptive: “In several respects, conscientiousness is an unusual personality trait. Because hunter-gatherer life did not require as much planning and memory for debts and duties as life in larger-scale societies with more complex...

Two strikes your out….Prozac doesn’t make the cut in Progressive MS…Again

Fluoxetine in progressive multiple sclerosis: The FLUOX-PMS trial. Cambron M, Mostert J, D’Hooghe M, Nagels G, Willekens B, Debruyne J, Algoed L, Verhagen W, Hupperts R, Heersema D, De Keyser J; FLUOX-PMS Study Group. Mult Scler. 2019 Jun 20:1352458519843051.  BACKGROUND: Preclinical studies suggest that fluoxetine has neuroprotective properties that might reduce axonal...

Is this the future?

If we believe that memory B cells are a problem them we may need to get rid of them. The problem is we have been stuck with the antibody approach, were we use antibodies to target B cells. The problem is that these clear out the blood but may not touch the cells in the lymph glands or the bone marrow and really don’t get into the brain very well. We know that CD8 T cells can get into the...

ECTRIMS a learning experience

Conferences traditionally play an important role in the ongoing medical education of healthcare professionals. We assessed the influence of attending the ECTRIMS congress on therapeutic decision-making in multiple sclerosis (MS) care. A non-interventional, cross-sectional study involving 96 neurologists was conducted. Treatment escalation when therapeutic goals were unmet and management errors...

Is fingolimod safe in pregnancy?

Safety of Disease Modifying Treatments (DMTs) whilst pregnant and breastfeeding (from Practical Neurology journal) The risk-mitigation strategies surrounding DMTs in pregnancy haven’t come that far over the last two decades. So far, we have abstain from pregnancy, stop treatment prior to pregnancy, stop if you discover that you’re pregnant, or switch to Copaxone during pregnancy...

Faecal transplant goes horribly wrong

This is one from ProfGs twitter feed. As you know I am a big fan of the value of microbiota 🙂 and the hundreds of trials of faecal transplant aiming to treat MS and every other condition. But be warned, if the Poop isn’t from a reputable source, things may not go the way you think. This Poop Transplant Resulted In A Death, FDA Warning via @forbes When you put someone else’s poop in...

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