More microbiome ceasarian sections and milk affect MS onset

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Caesarean section and infant formula feeding are associated with an earlier age of onset of multiple sclerosis. Dalla Costa G, Romeo M, Esposito F, Sangalli F, Colombo B, Radaelli M, Moiola L, Comi G, Martinelli V. Mult Scler Relat Disord. 2019;33:75-77

Mode of delivery and lactation are among the earliest factors influencing gut microbiota composition and potentially MS risk, but their contribution to MS susceptibility has been controversial. We investigated whether these factors could influence age at MS onset (AAO) on 2055 RRMS patients (mean age 28.4 years). Patients born by means of a caesarean section (10.9%) had an earlier AAO than those born through natural delivery (-5.2 years, p < 0.001). Patients fed with infant formula had an earlier AAO compared to patients breastfed, particularly considering those breastfed for at least 6 months (-4.2 years, p < 0.001). The association of vaginal delivery and natural breastfeeding with a later AAO of MS was particularly apparent in patients without a family history of MS, while disappeared in patients with familiarity for MS. The results suggest these modifiable environmental factors which act at the population level may have an influence on the onset of the disease.

11% of people with MS in this study italy were born by C-section and developed 5 years before people with a vaginal birth and 4 years early if you had formula verses breast milk. So not good news for the current generation”.

Breast milk is not only a completely adapted nutrition source for the newborn but also an impressive array of immune-active molecules that afford protection against infections and shape mucosal immune responses.

Decisive events might be modulated during the first months of life with potential health long-term effects, enhancing the importance of breastfeeding as a major influence on the immune system correct development and modifying disease susceptibility.

It has been reported previously that “Being breastfed was associated with a lower incidence of diabetes, celiac disease, multiple sclerosis and asthma, explained by the protection against early infections, anti-inflammatory properties, antigen-specific tolerance induction, and regulation of infant’s microbiome.” S0 there are alternative explanations to microbiobiome.

The protective role of human milk in idiopathic juvenile arthritis, rheumatoid arthritis, and inflammatory bowel diseases remains controversial. On the other hand, the breastfeeding mother faces a health-challenging period in life. High levels of prolactin may lead either to the development of autoimmune diseases in susceptible mothers or exacerbations of current immune-mediated disorders.

What does ProfG make of this?

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MouseDoctor

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  • **So not good news for the “too posh to push genertion:-)”.**

    That’s offensive.

    And generation has an ‘a’ in it.

    • It really is an offensive statement. In the 1970s, it was advised by NHS clinicians that formula milk was the best option for young mothers as it was formulated with the most optimised nutritional values for their new babies. This continued well into the 1980s, therefore, it was an advisory guidance mandated by those in charge of public health.

      The excuse of dyslexia is not an excuse for abundant stupidity.

      • And yet the rate of C-section delivery in the UK has now risen to 1 in 4 births in the UK, elective or otherwise.
        That may not be offensive but it is concerning, particularly in context of the above article, I’m sure you would agree.
        Also, ease up on the ad hominem.

        • When a baby is born vaginally, it is exposed to mum’s vaginal and intestinal flora, which is the start of your baby’s colonisation (also known as seeding). In a planned Caesarean, this doesn’t happen and babies are colonised with more disease-causing bacteria instead of ‘friendly’ bacteria.

  • Midwives are starting to promote vaginal swabs when a baby is born by Caesarean. Some people say this is an odd thing to do, but perhaps it might help with delaying MS onset in people born by Caesarean??

  • Hey Mousedoctor

    Usually you rock with your jokes and there is some evidence that elective caesareans by private patients are taking place buuut the too posh to push is a low blow to women who do have to have one.

    Yours feeling smug about two kids popped out the usual route and breast fed

    Vincentina

  • My daughter has MS. She was born by C section to avoid infant death or permanent disability. There was no choice.

    Six months of breast feeding followed her safe delivery.
    I did what I could.

    • I apologise if I seemed flipant, this behaviour comes out every time I post on observational associations with MS. There are always people who clearly did not do this and still got MS or vice versa and did not get MS. It is an endless stream of cause and effect if you look hard enough you find something.

      No doubt you could blame the increase in MS on watching Television or crisp (chip)-consumption etc etc. We get an endless list of these things. I always think of ice-cream sales I bet you could link MS to ice cream sales. I guess they change in winter and summer as does the month of birth effect. Then I could do a study of ice cream consumtpion and microbiota etecetc

      • Proud Mother, this certainly wasn’t a pop at you. It’s obvious you had a much needed C-section for health reasons, by what you state.

        Yes, MD there was a paper I read about MS and baked bean consumption as a child. Those who frequently had eaten baked beans as a child had a higher rate of MS.

          • That explains it! As a child my father would tell us “You can have beans on toast for lunch, or beans on toast or beans on toast” followed by a vendition of that little ditty ‘beans, beans are good for your heart…’ 😆

          • I had many meals with baked beans growing up. So yes Fi, it explains it.

            The mystery of MS has been solved!

  • My daughter was born of a natural delivery and never consumed formula
    Was diagnosed with MS at age 12, first symptoms were probably at 11

    So this story is rubbish

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