J Neuroimmunol. 2019 May 16;333:576966. doi: 10.1016/j.jneuroim.2019.576966. [Epub ahead of print]
Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis.
In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not known how this relates to the synthesis of oligoclonal IgG. We used quantitative mass spectrometry of oligoclonal bands and high-throughput sequencing of immunoglobulin heavy-chain variable transcripts to study the longitudinal B cell response in the cerebrospinal fluid (CSF) and blood of two MS patients. Twenty of 22 (91%) and 25 of 28 (89%) of oligoclonal band peptides persisted in samples collected 18 months apart, in spite of a dynamic exchange across the blood-CSF barrier of B lineage cells connecting to oligoclonal IgG.
This post is for Dr. Love who was asking about persistence of oligoclonal bands in MS. Once B cell clones arrive in the CNS and produce oligoclonal bands, they seem to persist. Even despite treatment with natalizumab. Therefore we need agents that can get in the brain to do their stuff. It seems obvious, doesn’t it. It’s surprising that they don’t always make agents to get in the brain. Can we get rid of them?. ProfG and NDG aim to find out