High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium. Häusler D, Torke S, Peelen E, Bertsch T, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS. Brain. 2019 Jul 13. pii: awz190.
We have had a discussion on the merits of Vitamin D and making models of MS worse. We have said that the vitamin D council suggests that too much vitamin D should be avoided.
MD2 has chipped in with this point
“The reason vitamin D is used as a mice and rat poison is because they are sensitive to it. It kills by inducing Hypercalcemia.”
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So it seems maybe in this EAE study they may have been poisoning their mice. Is this why disease got worse?
The lethal single dose for a mouse is about 40mg/kg (1mg a mouse) for a duck its 2000mg/kg showing the sensitivity to the rodents.
In bait the concentration is 0.075%. In the experiment it was 75000IU/kg in the diet so about 2mg/kg and a mouse eats about 3g a day (0.05mg of vitamin D), so a twentyith of a known lethal dose given every day for 2 months. Some people say up to 5g is eaten a day so closer towards a tenth of a lethal dose a day. The) so the dose given is not instantly lethal but if you are sick, it could tip the balance, we don’t know if there were any deaths in the experiment for example. This was not reported.
Moral of the story Read, Read Read