Cytomegalovirus primary infection in a patient with multiple sclerosis treated with alemtuzumab. Aguirre C, Meca-Lallana V, Sánchez P, Vivancos J.M ult Scler Relat Disord. 2019;5:270-271.
This comes as no relevation to anyone. One person I know who had alemtuzumab described themselves as “fungus mungus” because of the infections that can occur when you have no T or B cells.
Cytomegalovirus (CMV) is a common virus that can infect almost anyone. Once infected, your body retains the virus for life. Most people don’t know they have CMV because it rarely causes problems in healthy people.But if you’re have a weakened immune system, CMV is cause for concern.
CMV spreads from person to person through body fluids, such as blood, saliva, urine, semen and breast milk. There’s no cure for the virus. However, medications can help treat newborns and people with weak immune systems.
In this case report the virus was controlled naturally as “spontaneous recovery associated with rapid lymphocyte reconstitution”.
This shows why we need more specific therapies than a general sledgehammer
Is this coming. The late breaking news at ECTRIMS 2019 suggests it is
A. Lutterotti et al. Establish tolerance in MS with myelin-peptide coupled red blood cells – the phase Ib ETIMSredtrial,
The scientific programme with abstracts arrives this week (Click here). What are you interested in?
NGD & ProfB will be doing their live Google hangout again this year, so get you orders in about what to look for and what you want to hear about.
The Hangout is scheduled from 12.00-13.00 local time in Stockholm of Friday 13th September. Hope that isn’t an omen.
NGD has no doubt got a posh-frock sorted (By the way her water isn’t aquavit…Only joking NDG:-). ProfB will be off to Ikea to get a swedish flag and then maybe he’ll pop down to Asda for a new shirt.
As for the the phase Ib ETIMSred trial…. it will be safe, the T cell response to myelin peptide X will drop….but it won’t work properly . There’s the prediction….. I’ll have to wait and see. I can’t wait but why two reasons (a) Is the myelin peptide a myelin peptide (b) they won’t deplete before they do the tolerance. Will I eat my hat?