Memory B cells during Symptoms.

M

This study looks in the blood when someone gets a hearing problem..They find mature naive B cells. Are these the problem. Where are the memory B cells they aren’t there..Maybe they have moved out of the blood to cause the problem.

Lymphocytes B population profile in a case of multiple sclerosis presenting with sudden sensorineural hearing loss caused by a demyelinating pontine lesion.Dulamea AO, Musat GC, Lupescu IG, Popa CD.Mult Scler Relat Disord. 2019 Jul 28;35:170-175.

Sudden sensorineural hearing loss (SSHL) is a rare manifestation of multiple sclerosis, typically appearing in the early stages of the disease, especially in female subjects. SSHL is produced by the involvement of auditory tract, vestibulocochlear nerve and possibly cochlear structures and rarely due to a single lesion. The authors report the case of a young woman in which the onset of multiple sclerosis presented with SSHL caused by a pontine lesion. Oligoclonal bands in the cerebrospinal fluid (CSF) were absent at the disease onset and appeared during disease progression. Immunophenotyping of cells showed low cellularity of CD19+ cells in the CSF and expression of CD38+ on the majority of CD19+, CD20+ B cells in the peripheral blood, suggesting that many of them were mature B lymphocytes.

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