ArchiveOctober 2019

Zombie Science Today

Today is 31st October and it is Halloween. MD2 and I were taking about the shape of Science and sometimes it feels like we are fighting against some giant Zombie Army, who “can’t see the wood for the trees” You destroy the mindless naysayer only to be confronted by another and another and another. You can destroy them in so many ways but they keep on coming and coming. If you...

Buyers Club..Don’t Buy Duds.

ProfG has created an off-label list of DMT. Many of them are based on the generic version of current MS drug, or a generic pro-drug of an active MS drug. You perhaps would thought that Charities would want options for all people with MS, including those in resource-poor environments to have options. These studies could have been done by now, but my experience with generic cladribine told me...

Your race in MS

Race, ethnicity, creed – all architectural descriptors, some complex, others less so, depending on your perspective. When it comes to illnesses however, you are largely referencing race (the inheritance of your DNA) and ethnicity (the branch of race that your DNA occupies). We may be different in a number of ways, but our illnesses are a great equalizer. There is no such thing as race...

NDG forgot the paper

NDG forgot the paper details Efficacy and Safety of Alemtuzumab in Patients of African Descent with Relapsing-Remitting Multiple Sclerosis: 8-Year Follow-up of CARE-MS I and II (TOPAZ Study). Okai AF, Amezcua L, Berkovich RR, Chinea AR, Edwards KR, Steingo B, Walker A, Jacobs AK, Daizadeh N, Williams MJ; CARE-MS I, CARE-MS II, CAMMS03409, and TOPAZ Investigators. Neurol Ther. 2019 Oct 25. doi: 10...

Real life in Poland

When you select a DMT it is clearly not based on efficacy. Why not? I guess it is safety. If it were efficacy GA would not be doing so well in the sales. This study says what you all know, that GA is bottom of the pile. The label says it works by “mechanisms thought to be responsible for MS” and so we get a new mechanism with every new idea of how MS occurs. Therefore, it says to me...

Ocrelizumab touches a RAW spot, It also stops progression related disability

Before you read this paper you have to grasp the new concepts of RAW and PIRA. RAW is worsening in disability due to relapses and PIRA is progression independent of relapse activity. Therefore in PPMS, the progressive worsening would largely be a production of PIRA. RAW & PIRA a) Composite RAW and b) composite PIRA are the two non-mutually exclusive components/drivers of overall accumulation...

Do we really have equipoise about DMTs?

A guest post from Dr Emma Tallantyre, Cardiff. Definition: Clinical equipoise, also known as the principle of equipoise, provides an ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. In short, clinical equipoise means that there is genuine uncertainty in the expert medical community over whether a treatment will be beneficial...

Counting the cost, T2 lesions

Counting the cost and paying the price are not one and the same. For decades MRI has been the way by which all and sundry have monitored MS disease activity. But, what does it all mean? And, how good is it really? Recently, in a natural history evaluation of MS disease activity, the Barcelona group looked at MRI scans of those presenting to their centre on whom they had at least 10 years of...

A week too late to be the first, but more info on metformin and the remyelination story

Last week we had the suggestion that metforin can act as an anti-aging agent to make oligogendrocyte precursor cells to promote remyelination. This wasn’t the first time it had been suggested and it clearly was not the last. So this new study claims to be the first study to show metformin-induced AMPK ,could potentially accelerate regeneration . What a difference a week makes, becuase first...

Can you change your lifestyle?

I don’t know much about diet and multiple sclerosis, so we got ProfB to blag his way into the Houses of Parliment for a multiple sclerosis meeting on lifestyle and diet Chatting to the stars of the film can you guess who. It was the last time you will see that shirt The building reeks of history and it was pleasure to attend says ProfB. It was rather funny watching the Extinction Rebellion...

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