Smelling in MS, Is your nose running slow?

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Yep you get it all here folks, top science, neuros waxing lyrical and the down-right daft. So when I saw this little gem, I couldn’t help but write about it. I learn something every day. Hope you do.

Whilst we see if ProfG does his monday morning post or maybe he is off somewhere nice. He pops up to Sheffield to do teaching every now and then and its good that he gets to visit “Gods own Country“, even if it’s Sheffield:-)

This post reminds be of the motherland and when I was at Junior school. Every day at this time of year there was a large “greeno” in the urinals. I often wondered who hacked that up. Sniff it back and spit it out?. It was the land of the runny nose and the bogey Yep gross…but boys are, aren’t they?

Anyway, have you noticed a loss of the runney nose? This study suggests that your muscosal clearing is slower than in people how don’t have MS. Is this true? Or perhaps it’S NOT what this work is cracked-up to be.

For your and my info a saccharin test is a simple test of nasal mucociliary clearance, where a small particle of saccharin is placed approximately 1 cm behind the anterior end of the inferior turbinate…. Failure of sweetness to be detected within 10-20 minutes signifies delayed mucociliary clearance.

I did not know that.

Prof Hawkes will be loving this one as he has a specialism in loss of smell in MS. Has this happened to you? I knew someone who could not taste anything…. we used to got for a cup of hot water, it was a waste of time paying for coffee.

Measurement of mucociliary clearance in the patients with multiple sclerosis. Sahin E, Hamamcı M, Kantekin Y. Eur Arch Otorhinolaryngol. 2019 Nov 9. doi: 10.1007/s00405-019-05717-w. [Epub ahead of print]

OBJECTIVES: The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population.

METHODS: Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis and 50 healthy volunteers were enrolled into the study. Saccharin clearance test was performed on both groups and NMC time was measured. Data analysis was performed by SPSS version 24.0 statistics program (SPSS Inc., Chicago, Illinois, USA). Statistical tests were interpreted at p < 0.05 significance level.

RESULTS: The NMC time averages in MS patients and healthy control group were 12.43 ± 4.05 min and 8.14 ± 2.87 min, respectively; the difference between the groups was significant (p < 0.001). There was a statistically strong association between NMC time values and Expanded Disability Status Scale (EDSS) values in MS patients (r = 0.817, p < 0.001).

CONCLUSION: We found nasal mucociliary transport time longer in MS patients than healthy population in the present study. To the best of our knowledge, there is not any study conducted about this topic in the literature. We believe that our findings would shed a light on further studies.

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MouseDoctor

3 comments

  • My nose is constantly running any time of the year and i dont know what to do about that, seriuosly.
    So the pack of of handkerchiefs is of my go out check list any time of the year.
    (and not this is not related to substance abuse, cant even remember when this started)

  • As someone with RRMS, I find I have an enhanced sense of smell. Or maybe this is something MS has yet to take from me (or depends on lesion location?).

  • Hope the study took account of hydration levels. Dehydration = drier eyes, mouth, intestine (i.e. constipation), and nose.

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