ArchiveDecember 2019

Antibodies are important for some people with MS

Yesterday I was whinging about studies looking for anti-CNS antibodies and suggesting that they may be effect rather than cause, but are antibodies important. I would say almost certainly for some individuals and this post shows you why. Some people have circulating antibodies that are damaging and these can be removed from the blood. In this study people who did not respond well to a dose of...

Astrocytic disease control. Have we found the magic treatment for progressive MS

We have been spending all our time looking at T and B cells but there has been insufficient attention paid to the glial response, which is important given the the glial cells are probably very important in progressive MS. This study looks at astrocytes This paper looks at how astrocytes may be involved and the signalling molecules involved. I am sorry but I don’t have the time or the will...

MS world loses a true supporter

It is with great sadness I write that Chuck Barancik who – with his wife Margery – set up the Barancik Prize for Innovation in MS Research was killed on Wednesday in a car collision in Florida.  Earlier this year, I interviewed both him and Margery about the Barancik Prize – its inspiration and its goals. Though their philanthropic interests were wide, the promotion of MS...

Beating the dead horse abit more

This week we asked “LOOKING FOR AUTOIMMUNITY, IS IT FLOGGING A DEAD HORSE?” No sooner has our trusty Nag given its last breathe, it gets another whipping. Same story. The antibody occurs in a few people and they are against an internal proteins within a cell, suggesting an effect rather than a cause. Do I think these things cause problems? Absolutelty I do BACKGROUND: Nuclear antigen...

Copaxone..value for money?

You know my favourite MS drug…yep you guessed it,…..it’s glatiramer acetate. This has been doing the rounds since the 1970s and was the World’s favourite MS drug. I have to say that as an EAEer I have struggled to get it to do much, except in one certain way, hence my tounge in cheek reports. I obviously don’t have the green fingers of some of my colleagues. Perhaps...

Iranian MS Hypothesis

Dear Professor Gavin Giovannoni Significant increase in the incidence of multiple sclerosis in Iran has been always puzzling. With strong evidence from Danish MS Registry (Nielson et all) early environment rather than ones genetic is the primary etiological agent for Multiple sclerosis. Iran was exposed to this agent much earlier than other Gulf countries. British and Russian troops invaded Iran...

Gripes about DMF

In real-world terms, figures from the Swedish MS registry demonstrate that most PwMS discontinue a first-line DMT within 2 years of starting. Side effects make up bulk of the reasons, followed by lack of efficacy. When you consider highly-active treatments, their high efficacy outcomes go a long way to compensating for their down-side. When faced with the low efficacy drugs, their side effect...

Antibody levels drop after alemtuzumab as infections occur…lessons for ocreliziumab use

This study looks at the general antibody response after alemtuzumab and as you can see there is a tendency to go down. The authours suggest that these levels should be monitored in people requirng multiple infusions As a group you can see there is still massive overlap, but some individuals go a bit low and those with immunoglobulin (antibody) below normal limits are more likely to develop...

HSCT in Norge

The thing I learnt from the CCSVI saga was to light the touch paper and retreat, so make the post and say nothing. CCSVI has had its day and no we are frequented by the HSCT Brigade. This post will bring them out like abit of catnip. You can all read and have your opinion. I think targeting NEDA-3 is a more difficult ask, as progressive disability is a composite of two pieces of biology only one...

T cells and cortical Lesions is Siponimod the next thing to sort out cog fog?

What causes demyelination of the cortex creating grey matter lesions. Well in this study there is no difference to what causes demyelination in the spinal cord…It’s T cells, T cells, T cells. Cortical lesions have been associated with cog fog and so if you get rid of them surely that is great for progression. Siponimod is the new mod on the block and now we get data suggesting it...

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