Archive2020

MD2

ProfG wants the real MS to stand-up and asks about smouldering lesions. We think that hot microglia at the centre of these. A few years ago MD2 came up with the idea that antibodies within the oligoclonal bands could activate microglial by binding to receptors on the microglia and that may mean that it doesn’t matter what the antibodies are reactive against, so stop looking for anti-myelin...

Remyelination here we come…well almost. Bexarotene trial ECTRIMS

The basic science gives the tools for the clinicians to try and find treatments and Prof Franklinstein (Robin Franklin) from Cambridge and Prof ffffffffffrench-constant from Edinburgh hunted for molecules that may affect switches from precursors cells to full myelinating cells. They came up with a target that is triggered by the retinoid X receptor (RXR) gamma. Prof Franklin tried to get...

#MSCOVID19 Will CD20 treatment make you into a shedder

Typically when infected with SARS-CoV-2, you make an immune response and you get rid of the virus. But if you do not have an effective immune sytstem you can’t get rid of the virus and you can become a super spreader. Here is an interesting case that is not MS, but if you are CD20 depleting and you get that dry cough, fever and loss of smell think about your fellow humans and self-isolate...

#MSCOVID19: Interferon-beta and NABs

Barts-MS rose-tinted-odometer: ★ It is always nice to see evidence supporting a hypothesis you had more than a decade ago see daylight.  If you are on interferon-beta or have been on interferon-beta in the past this post is important to you. It is clear type 1 interferons, such as interferon-beta and alpha, are important antiviral cytokines and are critical in the body’s fight against...

T cells in MS brain

The central nervous system (CNS) features mechanisms to protect against untoward inflammation yet allowing immune surveillance for pathogens. Pappalardo et al. profiled T cells in the cerebrospinal fluid (CSF) of healthy individuals and patients with multiple sclerosis (MS) using single-cell RNA and TCR sequences to define CNS immune homeostasis in both healthy and patients with MS. In...

Confessions of an ECTRIMS fellow: what I really learned during my BartsMS fellowship

As you might have captured in one of my preceding blog posts, I’m relatively new to the MS research blog. There is a logical explanation for this: I only started to work at BartsMS in November 2019. With the purpose of converting me in an MS-ologist, I was one of the fortunate people to receive a clinical fellowship grant from the European MS association ‘ECTRIMS’.   The preceding ten...

Beyond NEDA: protecting the end-organ or your brain

Barts-MS rose-tinted-odometer: zero-★’s  It became clear to me at least 6 years ago that we need to go beyond NEDA (no evident disease activity) when treating MS and we have to focus on protecting the end-organ, i.e. normalising the brain volume loss that occurs in people with MS (pwMS). To do this you really need to diagnose and treat MS as effectively as possible early on. From a research...

ProfG has turned into a Smurf…Dear Neuro stop him turning into Papa!

ProfG has been banging-on about “Treat early and effectively to save brain”, until he is blue in the face….So much so, that he has turned into a Smurf Sadly there are still many of his colleagues that don’t buy into this… and follow the mantra of “There….There, we’ll get ya a nice wheel chair” The vast majority of neuros and pharma bods still...

#MSCOVID19 running the talk

Barts-MS rose-tinted-odometer: ★★★★★ In anticipation of a second-lockdown at a meeting with colleagues last night I was asked the question about what positive experiences I could reflect on from the first lockdown. Firstly, no international travel and a focus on family, home life and the realisation that we can live more sustainably. Secondly, walking or running the talk. I decided to take my own...

Shot down in flames before the VirtualMS dust has settled

Last weekend marked the eightieth anniversary of the Battle of Britain. In 1940, many planes were shot down in flames. Whilst this can happen to planes, this can also happen to ideas. Some of them take some time to be shot down, but sometimes they it takes less time. Who would have thought that some are shot down before they take off! This is super scientific so read on if interested OK not alot...

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