Archive2020

Carpe diem

Barts-MS rose-tinted-odometer: ★★★★★ I love science; it is such a thrill. I think science historians will look back at 2020 and the impact COVID-19 has had on science and scientific publishing and will define a new scientific era as being AC19 (after COVID-19) and the other era as BC19 (before COVID-19). The reason why I say this is because some of the changes that COVID-19 has induced in the...

ProfK launched ChariotMS last week. Case reports of COVID-cladribine

There has not been as much information about COVID-19 and oral cladribine as has occurred with anti-CD20. In view of the launch of ChariotMS by ProfK. This case report is welcome news in that both people who developed COVID were not hosptialised and recovered. They were relatively young and may be expected to recover but the fact that they had COVID shortly after treatment when the depleting...

#MSCOVID19 Viral Vaccines

We have heard about the RNA vaccines and today MEDCRAM (118) will tell you about the Oxford/Astrazeneca Vaccine. This is the vaccine that the UK has purchased the most of. I think it is unlikely that it will be offered to people on immunosuppressive DMT, although it is replication deficient and so should not be able to cause an infection. This week we had a nice email from Dr Seheult “Dear...

The ugly fruit

There is overwhelming public interest to support COVID-19 vaccine development. In fact many have already done this. As the UK gears up to participate in its third vaccine study called ENSEMBLE, a Phase 3 clinical trial with the Janssen developed Ad26-vectored vaccine candidate shortly with participants drawn from the NHS vaccines registry, the lack of transparent participant information is...

#MSCOVID19 Antibodies

casirivimab and imdevimab, bamlanivimab If you live in the USA the FDA has given emergency approval for two antibodies (one a cocktail of two antibodies 1.2g cashirivimab and imdevimab 1.2g) and the other a single 0.7g antibody (Bamlanivimab) available for the old age people likely to become severe to reduce the chance of hospitalization. It is not approved for severely affected people who are...

#MSCOVID19 Viral vaccines

I got a good kicking for for talking about an MS drug that we know is inferior to the big guns (High efficacy DMT), when the little guns (Lower efficacy DMT) is all that is offered. As I said, a little gun is better than no guns (OK bad analogy as Guns are bad! We should not have them and I am sure the National Rifle Association will be after me for this…yep I know many of our US readers...

When Fat is Useful: COVID-19 vaccine readiness and ocrelizumab

As you may know we have been publishing the trial results of ocrelizumab studies. The problem is that we write them in a style and manner that we chose and this may not be what pharma wants to say. This gives them an incentive to report the study before we say anything. If the information is out there in a readily searchable form (i.e a paper) then we have no incentive to report it. But if we say...

On the mend

Barts-MS rose-tinted-odometer: ★★ Prof G in hospital; an early Robinson Crusoe look Some commentators’ predictions were correct; when you are not well and are on the receiving end of the NHS as a patient you see things that you don’t necessarily see as an HCP and NHS employee. As a result of being ill with polytrauma and spending 14 days in the hospital, I  have acquired some insights that I...

HSCT and COVID-19 Mexican Style

I know there is great interest in HSCT and I also know any posts on HSCT is like catnip to the zealots. So I can’t be bothered to engage or defend as no matter what one says it is going to be wrong if is says something that people don’t want to hear. Removing your immune system puts you at serious risk from infection. Once you immune systme regenerates the risk goes away. This is...

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