Barts-MS rose-tinted-odometer ★ ★ ★ The good news is that the use of autologous HSCT to treat autoimmune diseases rose (by 19%) in the European Bone Marrow Transplant registry in 2018. Importantly, this rise was predominantly due to HSCT treatment for multiple sclerosis. This would indicate that at least at the very right of the bell curve there is increasing use of a more aggressive approach to...
Irony of Humanization part VI and a half DrAngry not only gave you a valentine present last week, that as MD2 says “Is better than chocolate and flowers” but in the process also gave Queen Mary students a big smile, as they saw their hard effort become a paper and a new tool to help neuros give better treatment to you. Last week we saw the first publication of a new technology to...
Barts-MS rose-tinted-odometer N/A Yesterday’s PMSA meeting was very interesting. It is clear the field of MS is at a cross-roads and that Pharma needs the wider MS community to help them change the game. If we don’t I suspect we won’t see the next generation of treatments being developed to target the ‘real MS’ or ‘smouldering disease’. It was clear...
Barts-MS rose-tinted-odometer – zero stars I am in Milan at the International Progressive MS Alliance Industry Forum Meeting. The aims of the meeting are to: Discuss challenges understanding and measuring progression and its impact on drug labelsDiscuss regulatory issues, opportunities and implications for drug labels and regulatory approvalsDiscuss links and opportunities for industry and...
This is up to you. it’s your choice. The important question is how do you make an antibody? I have to say all of them have their historical and technological origins in a furry beasty, notable mice and rats. You said “ I read that ocrelizumab was made from Chinese hamster ovary cells…. Is my ocrelizumab harvested inside a hamster?” Is the Hamster straining to push-out...
As clinicians so much of our time nowadays is focused on MS DMTs that we lack the time or forget to ask questions about general health and well being during our consults; for example, cognition, employment, co-morbidities and in some instances the risk of pressure ulcers. According to this publication (see below for abstract) 4% of PwMS have pressure ulcers; sacral ulcers being the commonest...
Failed vitamin D trial..Failed to infrom:-( ProfG has done a post on medical fiction. It is perhaps approriate to do a post on science fiction. As you know scientists are like sheep and they herd together and follow one and other. They stick close to the “dogma machine” and follow trends because, this is where money gets put. I have gone on the record of discussing a few. Some I have...
Barts-MS rose-tinted-odometer ★★★ Using fiction to teach and learn about MS is what I am turning to more and more. An old-fashion case scenario is a powerful tool for illustrating the difficulties we have in clinical neurology. We can create a clinical problem that is not necessarily answered by trial data or reading the summary of product characteristics. This is where clinical acumen and...
The expression of MAFG in mice is high compared to human (Data from public data bases MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ.Nature. 2020 Feb 12...
Barts-MS rose-tinted-odometer – zero stars We ran our third triMS-online this week and apart from a technical problem in the satellite symposium it went reasonably smoothly. The participants were very engaged and asked lots of questions. The topic of vaccination was particularly well received. Which vaccine? Component or live vaccines? When to give the vaccines and whether or not to delay...